BACKGROUND Recent prospective data suggest that intake of rapidly digested and absorbed carbohydrates with a high dietary glycemic load is associated with an increased risk of ischemic heart disease. OBJECTIVE We examined whether a high dietary glycemic load was associated with elevated hs-CRP concentrations and whether this association was modified by body mass index (BMI; in kg/m(2)). DES...

Sugars have a long history of safe use in foods. Placed on the Food and Drug Administration’s list of foods that are ‘‘generally recognized as safe’’ in 1958, sugars and the health aspects of sugar consumption continue to be evaluated. Recent research has focused on several potential sugars and health relationships, sugar consumption and nutritional quality of the diet, recommendations for suga...

BACKGROUND Although the associations of dietary glycemic index (GI) and dietary glycemic load (GL) with many chronic diseases have been examined in epidemiologic studies, information regarding the reproducibility and validity of these measures assessed with the use of food-frequency questionnaires (FFQs) is lacking. OBJECTIVE We examined the reproducibility and validity of dietary GI and diet...

We read with interest the article by C. R. Jonas et al. showing no association between dietary glycemic index or glycemic load and breast cancer in the Cancer Prevention Study II Nutrition Cohort. We similarly examined the relation between usual glycemic index and load derived from a food frequency questionnaire (1) over 15 years of follow-up (1986–2000) in 34,703 postmenopausal women initially...

BACKGROUND Although the pathogenesis of acne is currently unknown, recent epidemiologic studies of non-Westernized populations suggest that dietary factors, including the glycemic load, may be involved. OBJECTIVE The objective was to determine whether a low-glycemic-load diet improves acne lesion counts in young males. DESIGN Forty-three male acne patients aged 15-25 y were recruited for a ...

BACKGROUND Little is known about the effects of the amount and type of carbohydrates on risk of coronary heart disease (CHD). OBJECTIVE The objective of this study was to prospectively evaluate the relations of the amount and type of carbohydrates with risk of CHD. DESIGN A cohort of 75521 women aged 38-63 y with no previous diagnosis of diabetes mellitus, myocardial infarction, angina, str...

Although diet is believed to influence colorectal cancer risk, the long-term effects of a diet with a high glycemic load are unclear. The growing recognition that colorectal cancer may be promoted by hyperinsulinemia and insulin resistance suggests that a diet inducing high blood glucose levels and an elevated insulin response may contribute to a metabolic environment conducive to tumor growth....