نتایج جستجو برای: glucosidase inhibitors
تعداد نتایج: 194978 فیلتر نتایج به سال:
α-Glucosidase inhibitors are effective in controlling postprandial hyperglycemia, which play crucial roles the management of type 2 diabetes. Protocatechuic acid (PCA) is one phenolic acids existing not only various plant foods but also as a major microbial metabolite dietary anthocyanins large colon. The present study investigated inhibitory mechanism PCA on α-glucosidase <em...
Diabetes is considered one of the biggest health crises in 21st century. Controlling carbohydrate digestibility by inhibiting starch digestive enzyme (α-amylase and α-glucosidase) activities an efficient strategy to control postprandial hyperglycemia. Over last decade, synthetic inhibitors are most effective pharmaceutical approach for management type 2 diabetes mellitus (T2DM). With increasing...
AIMS/INTRODUCTION To assess the efficacy and safety of sitagliptin compared with α-glucosidase inhibitors in Japanese patients with type 2 diabetes inadequately controlled by metformin or pioglitazone alone. MATERIALS AND METHODS In the present multicenter, randomized, open-label, parallel-group, active-controlled, non-inferiority trial, 119 patients aged 20-79 years with type 2 diabetes who ...
The α-glucosidase inhibitory activity of an aqueous extract and compounds from the aerial parts of V. corymbosa was demonstrated with yeast and rat small intestinal α-glucosidases. The aqueous extract inhibited yeast α-glucosidase with a half maximal inhibitory concentration (IC50) of 28.6 μg/mL. Bioassay-guided fractionation of the extract led to the isolation of several compounds, including o...
This article is a brief review of the current non-insulin agents for diabetes mellitus in the United States, namely, sulfonylureas, biguanides, thiazolidinediones, meglitinides, α-glucosidase inhibitors, glucacon-like peptide-1 receptor agonists, dipeptidyl-peptidase-4 inhibitors, amylin agonists, bromocriptine, and colesevelam.
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