We retrospectively compared two computerized IV insulin-treatment protocols, eProtocol-insulin and Glucosafe, insilico using ICU data. We used clinical data from eProtocol-insulin supported cohorts to simulate patient models in Glucosafe. The amounts of insulin recommended by these protocols were compared and evaluated at different blood glucose ranges. Results indicated that Glucosafe consiste...

diabetes is considered as a global affecting disease with an increasing contribution to both mortality rate and cost damage in the society. therefore, tight control of blood glucose levels has gained significant attention over the decades. this paper proposes a method for blood glucose level regulation in type 1 diabetics. the control strategy is based on combining the fuzzy logic theory and si...

In type 2 diabetes mellitus (DM2), the impaired functions of brain insulin system are associated with weakened transport through blood-brain barrier due to resistance. Insulin deficiency in can be corrected by intranasal administration (II), whose effect may enhanced C-peptide (ICP). this work, we study treating hyperinsulinemic and normoinsulinemic DM2 rats ICP (36 µg/rat/day), II (20 µg/rat/d...

Introduction: Sonophoresis has been assessed as a novel approach to create skin permeability and drug delivery using low frequencies of ultrasound waves in the range of 20 kHz to 3 MHz. In this study, a system including seven 40 kHz piezoelectric transducers and an insulin chamber designed by the Medical Physics Research Center has been evaluated on hyperglycemic rabbits. Materials and Methods:...

Closed loop system for diabetes mellitus compensation was developed. The system comprises a non-invasive optical glucose meter, an insulin infusion device and algorithm for blood glucose prediction. Glucometer consists of the control unit connected to the earlap clip by optical fiber. Experimental trials show that inherent accuracy of the optical system is 0.012 %, reproducibility – 0.06 %, RMS...

The aim of the work reported herein was to study the effect of glucosamine HCl (GlcN·HCl) on the bioactivity (BA) of insulin, administered via subcutaneous (SC) and oral routes, in adult male Sprague Dawley rats. The oral insulin delivery system (insulin-chitosan reverse micelle [IC-RM]) was prepared by solubilizing insulin-chitosan (13 kDa) polyelectrolyte complex in a RM system consisting of ...

in this study, the effects of late gestational undernutrition (lgu) on plasma concentration of insulin-like growth factor 1 (igf-i), leptin, insulin and glucose in subsequent sucking lambs was investigated. ten twin-bearing ewes were fed either restrictedly (restricted) or adequately (control) during the last six weeks of gestation and were fed ad libitum after parturition. blood samples were t...

BACKGROUND Persistent hyperglycemia is common in alpacas and typically requires insulin administration for resolution; however, little is known about alpacas' response to different insulin formulations. OBJECTIVES To evaluate the effects of 3 insulin formulations on blood glucose concentrations and the use of a continuous glucose monitoring (CGM) system in alpacas. ANIMALS Six healthy alpac...