B3 is a tumor-reactive monoclonal antibody (mAb) that binds to a limited number of normal tissues. Immunotoxins made with B3 coupled to either Pseudomonas exotoxin (PE) or recombinant forms of PE with a deletion of the cell-binding domain (LysPE40) have been shown to cause complete tumor regression in nude mice bearing a rapidly growing A431 (L. H. Pai et al., Proc. Natl. Acad. Sci. USA, 88: 33...

b3-Adrenoceptor agonists have recently been introduced for the treatment of overactive urinary bladder syndrome. Their target, the b3-adrenoceptor, was discovered much later than b1and b2-adrenoceptors and exhibits unique properties which make extrapolation of findings from the other two subtypes difficult and the b3-adrenoceptor a less-understood subtype. This article discusses three aspects o...

Introduction Lessons captured from interviews with 12 European regions are represented in a new instrument, the B3-Maturity Model (B3-MM). B3-MM aims to assess maturity along 12 dimensions reflecting the various aspects that need to be managed in order to deliver integrated care. The objective of the study was to test the content validity of B3-MM as part of SCIROCCO (Scaling Integrated Care in...

Increasing evidence suggests that AR (androgen receptor) acetylation is critical for prostate cancer cell growth. In the present study, we identified Pro-B3 (procyanidin B3) as a specific HAT (histone acetyltransferase) inhibitor. Pro-B3 selectively inhibited the activity of HATs, but not other epigenetic enzymes. Pro-B3 substantially inhibited the p300-mediated AR acetylation, both in vitro an...

Abstract 
 Moringa leaves (Moringa oleifera Lam) is one of the potential local feed ingredients broiler rations due to its nutrient contents such as carbohydrate (57,01%), crude protein (30,30%), fat (2,74%) well a source vitamin C, carotenoids and flavonoids. This study aimed determine effect using different levels Lam leaf meal (MOLM) in basal ration on plasma metabolites, including tota...

Integrins are transmembrane receptors composed ofa andb subunits that mediate bidirectional signaling between the extracellular matrix and the cell interior. Among the best studied integrins is aIIbb3, which is required for hemostasis and platelet involvement in thrombosis. The related b3 integrin, aVb3, is expressed at low levels in platelets and better expressed in several other hematopoietic...

high molecular weight (hmw) subunits of wheat glutenin are generally considered as playing a key role in gluten formation and structure, as well as to be closely related to wheat quality. the endosperm storage proteins of 80 synthetic lines and wheat cultivars (triticum aestivum) were fractionated through sodium dodecyl sulfate polyacrylamide gel electrophoresis to determine their high-molecula...

The Gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems are implicated in depression. While previous studies found reduced GABA levels, a tendency towards Glu, using proton (1H) magnetic resonance spectroscopy (1H-MRS), little is known about GABAA receptor availability Here, the aim was to characterize Glu-levels dorsal anterior cingulate cortex (dACC), whole-brain avail...

The accumulation of proline impacts the defense mechanisms plants against harmful effects adverse environmental conditions; however, its concentration in is associated with metabolism N. Therefore, exogenous organic [glutamate (Glu)/arginine (Arg)] and inorganic [nitrate (NO3−)/ammonium (NH4+)] N on (Pro) rice under trivalent chromium [Cr(III)] stress were studied through using mass balance mat...

Sustained infection of HeLa cells by Coxsackie B3 virus, dependent on presence of viral inhibitor in culture medium, was achieved. Persistent treatment of carrier cultures with anti-Coxsackie B3 hyperimmune monkey serum eventually eliminated virus from carrier cultures indicating that a lysogenic virus-cell relationship was not operative. Free virus was produced continuously by carrier cultures...