In view of the availability of new immunosuppression strategies, the recurrence of allograft glomerulonephritis (GN) are reported to be increasing with time post transplantation. Recent advances in understanding the pathogenesis of the GN recurrent disease provided a better chance to develop new strategies to deal with the GN recurrence. Recurrent GN diseases manifest with a variable course, st...

Post-infectious acute glomerulonephritis with hypertensive encephalopathy is characterized by episodic hypertension with headache, vomiting, and hematuria. The association between hypertensive encephalopathy and cortical blindness in children with acute glomerulonephritis is extremely rare. We report the case of a 10-year-old boy with acute glomerulonephritis who presented with gross hematuria,...

Rare bacteria can lead to infective endocarditis, which may lead to renal involvement as severe glomerulonephritis. We report our experience of a 12-year-old child who presented with infective endocarditis and blood culture-grown Gemella morbillorum - a rarely reported bacteria. The clinical picture was further complicated with severe glomerulonephritis. Renal biopsy was suggestive of crescenti...

TNF is an important cytokine and acts as mediator of inflammatory tissue damage which is caused by immunologically mediated processes. TNF provides its effects via two signalling pathways using its two receptors, TNFR1 and TNFR2. In 2005 Vielhauer et al. revealed that TNFR2 plays an important role in the development of glomerulonephritis, which is one of the most important causes for renal fail...

Features of crescentic glomerulonephritis suggest that it results from a T helper 1 (Th1) nephritogenic immune response. Interferon-gamma (IFN-gamma), produced by Th1 cells, is involved in T cell-directed macrophage activation in effector Th1 responses. The hypothesis that endogenous IFN-gamma contributes to the development of crescentic glomerulonephritis was tested by comparing the developmen...

objectives this report describes the indication, histopathological patterns, and epidemiology of renal diseases in children in india. patients and methods this is a single-center study on renal biopsies performed between january 2008 and december 2013 in 346 children (age ≤ 14 years). results eleven (3.17%) biopsies were inadequate, and 335 biopsies were considered for analysis. the mean age wa...

conclusions the occurrence of sam in pauci-autoimmune vasculitis is rarely described, particularly in africa. our case is an illustration of the reality of this association. introduction we reported a case of hemophagocytic syndrome complicating microscopic polyangitis presented by crescentic glomerulonephritis. case presentation a 22-year-old female patient originated from dakar, senegal prese...

Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) is a recently described entity. It is featured by glomerular nonorganized monoclonal immunoglobulin G deposits. Monoclonal IgG deposits are associated with glomerular proliferative lesions, mimicking different types of immune-complex glomerulonephritis. We report two classic cases of PGNMID which fulfilled all criteria of th...

We report a case of mesangial proliferative glomerulonephritis with interstitial nephritis associated with multicentric Castleman's disease (MCD) successfully treated with an anti-interleukin-6 receptor antibody (tocilizumab). This mesangial proliferative glomerulonephritis with interstitial nephritis was resistant to methylprednisolone treatment; however, it was markedly improved with tocilizu...

Horseshoe kidney is a relatively common renal anomaly with which many structural and developmental anomalies have been shown to be associated. However, there are only a few case reports regarding the association of membranous glomerulonephritis and focal sclerosing glomerulonephritis in patients with horseshoe kidneys. We report a girl who was evaluated for hematuria and proteinuria, and found ...