Background: Guidelines recommend estimating glomerular filtration rate (GFR) using creatinine-based equations (CBE).

Objective Selective angioembolization (SAE) effectively diagnoses and treats iatrogenic vascular complications following percutaneous nephrolithotomy (PCNL). Methods We retrospectively reviewed 1329 consecutive PCNLs and identified patients who underwent SAE following PCNL with at least 12-month follow-up. Estimated glomerular filtration rate (eGFR) was calculated for all patients preoperativ...

The link between changes in a subject's metabolic syndrome components and her estimated glomerular filtration rate (eGFR) was evaluated in healthy Japanese women. We used data for 53 Japanese women (46.0±10.9 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. There were no significant relationships between eGFR and clinical parameters at baseline. Subjects w...

We have previously demonstrated that loss of renal functional reserve (renal response to protein loading) in two-kidney, one clip Goldblatt hypertension is characterized by no change in glomerular filtration rate or single nephron glomerular filtration rate and decreased absolute proximal tubular reabsorption during glycine administration. Captopril restores proximal reabsorption and renal func...

This review summarizes the available evidence concerning the relationship between renal dysfunction and cardiovascular risk in non-diabetic patients. Based on numerous studies, there remains no more doubt today, that even minor renal dysfunction, as reflected by microalbuminuria and/or decreased estimated glomerular filtration rate, causes a dramatic increase in cardiovascular risk. Renal dysfu...

BACKGROUND/OBJECTIVE Plasma-creatinine-based equations to estimate the glomerular filtration rate are recommended by several clinical guidelines. In 2009, Schwartz et al. adapted the traditional Schwartz equation to children and adolescents but did not find different k-coefficients between children and adolescents (k = 36.5 for all patients). We reevaluated the coefficient of the 2009-Schwartz ...

This study was designed to test the hypothesis that a reduced number of nephrons from birth leads to increased arterial pressure in adulthood. Newborn Sprague-Dawley rat pups were uninephrectomized during the first 24 h after birth. In chronically instrumented adult animals (∼22 wk), mean arterial pressure on a normal (0.20%)-Na+ diet was higher in uninephrectomized rats (133 ± 2 mmHg vs. 121 ±...

Darunavir is an efficacious drug; however, pharmacokinetic variability has been reported. The objective of this study was to find predisposing factors for low darunavir plasma concentrations in patients starting the once- or twice-daily dosage. Darunavir plasma concentrations from January 2010 till December 2014 of human immunodeficiency virus-infected individuals treated in the outpatient clin...

From the Division of Nephrology, Tufts– New England Medical Center, Boston (L.A.S., A.S.L.); the Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore (J.C.); and the Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland (T.G.). Address reprint requests to Dr. Stevens at Tufts– New England Medical Center, 750 Washington St., Box 391, Boston, MA 0...