A cascading system of hierarchical, artificial neural networks (named PRED-CLASS) is presented for the generalized classification of proteins into four distinct classes-transmembrane, fibrous, globular, and mixed-from information solely encoded in their amino acid sequences. The architecture of the individual component networks is kept very simple, reducing the number of free parameters (networ...

The translocation process of a globular protein (ubiquitin) across a cylindrical nanopore is studied via molecular dynamics simulations. The ubiquitin is described by a native-centric model on a Calpha carbon backbone to investigate the influence of protein-like structural properties on the translocation mechanism. A thermodynamical and kinetic characterization of the process is obtained by stu...

We have studied a model of a complex fluid consisting of particles interacting through a hard-core and short-range attractive potential of both Yukawa and square-well form. Using a hybrid method, including a self-consistent and quite accurate approximation for the liquid integral equation in the case of the Yukawa fluid, perturbation theory to evaluate the crystal free energies, and mode-coupli...

We present the study of dynamical status globular cluster NGC 1851. A combination multiwavelength space and ground-based data sets are used for analysis. In order to select genuine members, we astro-photometric available from HST GAIA-DR2 catalogs. The BSS radial distribution is plotted center outskirts. shows a central peak, followed by dip at intermediate radii (rmin ~ 90'') rising trend in a...

in this work, we define a fuzzy soft set theory and its related properties. we then define fuzzy soft aggregation operator that allows constructing more efficient decision making method. finally, we give an example which shows that the method can be successfully applied to many problems that contain uncertainties.

Protein crystallization, aggregation, liquid-liquid phase separation, and self-assembly are important in protein structure determination in the industrial processing of proteins and in the inhibition of protein condensation diseases. To fully describe such phase transformations in globular protein solutions, it is necessary to account for the strong spatial variation of the interactions on the ...

BACKGROUND Although it has been estimated that pandemic Influenza A H1N1/2009 has infected millions of people from April to October 2009, a more precise figure requires a worldwide large-scale diagnosis of the presence of Influenza A/H1N1/2009 antibodies within the population. Assays typically used to estimate antibody titers (hemagglutination inhibition and microneutralization) would require t...

We present a method to identify all compact, contiguous-chain, structural units in a globular protein from x-ray coordinates. These units are then used to describe a complete set of hierarchic folding pathways for the molecule. Our analysis shows that the larger units are combinations of smaller units, giving rise to a structural hierarchy ranging from the whole protein monomer through supersec...

We consider a multiple-rule, generalized modus ponens inference scheme, with an interpretation based on compositional rule of inference (CRI) and a residuated implication. We show that such a system is equivalent, as far as CRI is concerned, to a system that satis5es the “basic requirement for fuzzy reasoning”, proposed by Turksen and Tian (Fuzzy Sets and Systems 58 (1993) 3–40). We establish a...

The description of the error dynamics (30) in our paper [1] contains an omission that leads to some bounds used in the conditions of Theorem 8 and Corollary 2 in the paper to be incorrectly defined. In what follows, the correct error dynamics and the corresponding conditions are given. Instead of (30) in [1], the error dynamics are actually given by ė = m ∑ i=1 wi(z)[(Ai − LiC +MiAδi)e +Mi(Āδix̂...