Ingestion of diets containing Aroclor 1254, a mixture of polychlorinated biphenyls, for 2 years led to a dose-related increase in the incidence of focal lesions in the glandular stomachs of male and female F344 rats. The incidence of stomach lesions was 6% in control specimens and in specimens from rats fed a diet containing 25, 50, or 100 ppm Aroclor 1254, the incidences of stomach lesions wer...

Gastric adenomyoma (GA) is a rare benign lesion, most frequently found in the pyloric/antral region of the stomach. It consists of a mixture of smooth muscle and glandular structures, occasionally cystically dilated, lined by tall columnar epithelium, Brunner’s glands, and sometimes pancreatic parenchyma. In this report, we describe an unusual case of adenomyoma of the fundus of the stomach, wh...

Helicobacter pylori (Hp) is thought to be a stomach carcinogen from epidemiological findings. To determine the effects of infection with the bacteria on experimental carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. Male MGs were treated with N-methyl-N'-nitro-N-nitrosoguanidine followed by inoculation with Hp or infected with Hp followed by N-methyl-N'-...

In the stomach of rodents clusters of brush cells are arranged at the "gastric groove," immediately at the transition zone from the non-glandular reservoir compartment to the glandular digestive compartment. Based on their taste cell-like molecular phenotype it has been speculated that the cells may be capable to sense constituents of the ingested food, however, searches for nutrient receptors ...

Myoepithelial hamartoma is a very rare submucosal tumor of the stomach. Magnus-Alsleben first described 5 cases of this tumor in 1903. More recently (1993) Vandelli et al. published a review of the literature comprising only 33 cases. Histologically, the tumor is characterized by hypertrophic smooth muscle bands surrounding diverse epithelial elements that can be arranged in different ways: as ...

properties. In these studies a large number of solvents were employed for the administration of 3,4-benzpy rene. The solutions of the hydrocarbon were in stilled into the stomachs of mice and cats and the rate of the absorption of the fluorescent carcinogen determined directly in the wall of the stomach in the manner described in the first paper of this series (7). The intensity of fluorescence...

N-Nitrosocimetidine, a nitroso derivative of the drug cimetidine, was given to groups of 20 male and 20 female rats in drinking water at a concentration of 0.5 mM for more than 2 years. The life span of the rats was not decreased compared with untreated control animals, and there was no significant increase in incidence of any tumor that could be attributed to the treatment. In comparison, 45% ...

Gastric Ulceration in the Adult Gastric ulceration syndrome (GUS), a complicated and multi-factorial problem, is a common disorder of the stomach of mature horses. Horses that are turned out to pasture and are not involved in work have normal stomachs as do most horses used for light work or pleasure (Murray 1994). In recent years the widespread nature of this disorder has gained increased reco...

Transforming growth factor alpha (TGF alpha) is thought to participate in the normal and pathologic processes of numerous tissues, including the gastric mucosa. To explore its role in vivo, transgenic mice were generated overexpressing TGF alpha in the stomach. TGF alpha induced dramatic structural and functional lesions of the glandular stomach that were similar to Ménétrier's disease in human...