نتایج جستجو برای: gist tumor
تعداد نتایج: 430446 فیلتر نتایج به سال:
Gastrointestinal stromal tumor (GIST) occurring in the pediatric population has a unique biology and natural history when compared to GIST occurring in adults. As a result of these unique features, management of GIST in children may need to differ from management of GIST in adults. GIST is a very rare disease in children. Consequently prospective clinical trials have not been performed. A revie...
PURPOSE: The radiologic findings of GIST have been well described in the radiology literature. However, there were few reports that had reported the MR imaging features of GIST. Therefore, the aim of this study is to describe the MR imaging features of GIST of the gastrointestinal (GI) tract. METHODS: We retrospectively reviewed the pathologic and medical records from January 2007 to September ...
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract and arises from the interstitial cells of Cajal. It is characterized by expression of the receptor tyrosine kinase CD117 (KIT). In 70-80% of GIST cases, oncogenic mutations in KIT are present, leading to constitutive activation of the receptor, which drives the proliferation of these tumors. Treatment...
Although treatment with imatinib, which inhibits KIT and PDGFR, controls advanced disease in about 80% of gastrointestinal stromal tumor (GIST) patients, resistance to imatinib often develops. RACK1 (Receptor for Activated C Kinase 1) is a ribosomal protein that contributes to tumor progression by affecting proliferation, apoptosis, angiogenesis, and migration. Here, we found that c-KIT binds t...
BACKGROUND Little is known about the factors that predict for gastrointestinal stromal tumor (GIST) recurrence in patients treated with adjuvant imatinib. METHODS Risk factors for GIST recurrence were identified, and 2 risk stratification scores were developed using the database of the Scandinavian Sarcoma Group (SSG) XVIII trial, where 358 patients with high-risk GIST with no overt metastase...
OBJECTIVES Gastrointestinal stromal tumor (GIST) is characterized by KIT or PDGFRA gene mutation. Although chromosomal losses of 22q are frequent in GIST, it is unclear which tumor suppressor genes might be inactivated in association with such losses. The INI1 gene, located at 22q11.23, is a tumor suppressor gene that is frequently altered in malignant rhabdoid tumor. METHODS To elucidate the...
RATIONALE Gastrointestinal stromal tumor (GIST) is the neoplasm of gastrointestinal tract. PATIENT CONCERNS The patient complained about the retention of urinary. DIAGNOSES GIST. INTERVENTIONS radical prostatectomy and the imatinib therapy. OUTCOMES No recurrence and metastasis have been found during a 14-month follow-up. LESSONS comprehensive treatment is necessary for the GIST treat...
KIT and / or PDGFRA activation mutation is the initial molecular event of gastrointestinal stromal tumor (GIST), mechanism leading to malignant progression GIST needs be further studied broken through. This study aims understand from perspective metabolic reprogramming provide a new target for treatment GIST. In present study, transcriptome metabolome were used test tissue adjacent normal sampl...
UNLABELLED Intra-abdominal fibromatosis (IAF) commonly develops in patients who had abdominal surgery. In rare instances, it occurs subsequent to gastrointestinal stromal tumor (GIST). This special situation has clinical significance in imatinib era. About 1000 patients with GIST in our institution from 1993 to 2010 were re-evaluated based on their clinical and pathological data, the treatment ...
gastrointestinal stromal tumors (gists) are rare and these tumors are mesenchymal tumors that develop in the wall of the gi tract. the aim of this study was to report a case with gist in pregnancy in western iran. a 39-year-old pregnant female (g5 p4) was admitted with a chief complaint of abdominal pain and epigastric fullness on 12 th april 2016. sonography showed gestational age of 15w+1d an...
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