In the last decade a tremendous amount has been learned about the biology and treatment of gastrointestinal stromal tumor (GIST). Imatinib mesylate has revolutionized the treatment of metastatic GIST. In addition, the role of imatinib in localized GIST has gained much interest and may improve patient outcomes. Additionally, research efforts aimed at understanding the biology and the molecular h...

Gastrointestinal stromal tumors (GIST) are the most common adult sarcomas and the oncogenic driver is usually a KIT or PDGFRA mutation. Although GISTs are often initially sensitive to imatinib or other tyrosine kinase inhibitors, resistance generally develops, necessitating backup strategies for therapy. In this study, we determined that a subset of human GIST specimens that acquired imatinib r...

Gastric plexiform fibromyxoma (PF) is a rare mesenchymal tumor with a histologically distinctive multinodular pattern, dissimilar to conventional gastrointestinal stromal tumor (GIST). The current study presents one case of gastric PF, and one case of GIST with a platelet-derived growth factor receptor α (PDGFRA) mutation mimicking PF, and discusses their differential diagnoses. The two patient...

Currently available data on prognostic implication of additional neoplasms in GIST miss comprehensive information on patient outcome with regard to overall or disease specific and disease free survival. Registry data of GIST patients with and without additional neoplasm were compared in retrospective case series. We investigated a total of 836 patients from the multi-center Ulmer GIST registry....

Determining whether patients with amnesia can succeed in remembering their distant past has pivotal implications for theories of memory storage. However, various factors influence recall. We speculated that some patients with anterograde amnesia adopt a gist-based retrieval orientation for memories from all time periods, thereby exaggerating remote recall deficits. We tested whether an experime...

Students struggle to read science texts. This is especially problematic for designers of inquiry-based learning environments that make ambitious demands on readers. We report on our efforts to provide targeted strategic supports for struggling adolescent readers in science classrooms. Environmental science and biology high school students learned to use tools designed to foster three specific m...

In this paper we review DMSumm, an automatic summary generator based on a discourse model that combines semantic, rhetorical and intentional knowledge. We assess the automatic results in the light of three basic constraints: gist preservation, communicative goal satisfaction and textuality.

PURPOSE: The radiologic findings of GIST have been well described in the radiology literature. However, there were few reports that had reported the MR imaging features of GIST. Therefore, the aim of this study is to describe the MR imaging features of GIST of the gastrointestinal (GI) tract. METHODS: We retrospectively reviewed the pathologic and medical records from January 2007 to September ...