BACKGROUND Drug-induced gingival overgrowth is a frequent adverse effect associated principally with administration of the immunosuppressive drug cyclosporin A and also certain antiepileptic and antihypertensive drugs. It is characterized by a marked increase in the thickness of the epithelial layer and accumulation of excessive amounts of connective tissue. The mechanism by which the drugs cau...

A 55-year-old man was referred to us because of renal dysfunction (serum creatinine 1.82 mg/dL). Three years earlier, he had aortic dissection associated with left renal artery occlusion and had undergone surgery for ascending aorta and aortic arch replacement. He had been receiving the following medications for 3 years; nifedipine (Adalat-CR) 40 mg, carvedilol 10 mg, aspirin 100 mg, allopurino...

Severe gingival overgrowth is one of the most frequent side effects in renal transplant patients associated with assumption of cyclosporine A. Several associations with age, sex, dosage, duration of therapy or interval since transplantation have been hypothesized. The introduction of alternative immunosuppressant drugs have been suggested to permit better long-term transplant outcomes and a dec...

BACKGROUND AND OBJECTIVE Collagen type I elevation in cyclosporin A-induced gingival overgrowth supports evidence that gingival fibroblasts play a decisive role in the manifestation of the phenotype. To analyze the role of gingival fibroblasts under more in vivo-like conditions, we evaluated the effect of cyclosporin A on collagen type I gene and protein expression in gingival overgrowth-derive...

amyloidosis includes a wide range of disorders characterized by deposition of amyloid in different organs and tissues. localized gingival enlargement due to accumulation of amyloid without involvement of other organs is a very rare condition. this article describes a 31-year-old male patient with amyloidosis involving only the periodontium of the anterior mandibular teeth with localized severe ...

Gingival overgrowth/hyperplasia can be attributed to several causes, but drug-induced gingival overgrowth/hyperplasia arises secondarily to prolonged use of antihypertensive drugs, anticonvulsants and immunosuppressants. The management is complex in nature considering the multitude of factors involved such as substitution of drug strict plaque control along with excision of the tissue to be per...

Gingival overgrowth is well documented side effect associated with three major classes of drugs viz, anticonvulsants, calcium channel blockers, and immunosuppressants. Despite our greater understanding of pathogenesis of Drug induced Gingival Overgrowth (DIGO), its treatment still remains a challenge for the periodontists and treatment is still largely limited to maintenance of improved level o...