Gingival overgrowth is one of most frequently encountered lesion of oral cavity. Most of them are innocuous and arise due to localised irritation. They are termed broadly as “Epulis”. Peripheral ossifying fibroma is one of them with considerable variation regarding its nomenclature and etiopathogenesis. This case report presented 27 years old male with gingival overgrowth in maxillary anterior ...

To cite: Chacko LN, Abraham S. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014204670 DESCRIPTION Gingival overgrowth occurs as a side effect of some systemic medications. It is now well established that phenytoin is one such agent. It has multiple therapeutic indications ranging from convulsive disorders and neuralgias to cardiac arrhythmia. The incidence rat...

Gingival enlargement or gingival overgrowth is the abnormal growth of periodontal tissues. Drug induced gingival enlargement is one of the most common cause of enlarged gingiva. Drugs associated with gingival enlargement are divided in to three major groups namely anticonvulsants, immunosuppressant and calcium channel blockers [1]. Among the anticonvulsants, phenytoin is most commonly associate...

Drug-induced gingival overgrowth is a side effect associated with 3 types of drugs: anticonvulsants (phenytoin), immunosuppressive agents (cyclosporine A), and various calcium channel blockers for cardiovascular diseases. Gingival overgrowth is characterized by the accumulation of extracellular matrix in gingival connective tissues, particularly collagenous components with various degrees of in...

The administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty y...