Giant cell tumor (GCT) is a benign primary bone neoplasm that usually occurre in the long bones. The skull is affected in only 1% of cases, predominantly in the sphenoid and temporal bones. Maxillary sinus involvement is exceedingly rare. The case is a 26 year-old man presented with history of gradually increasing swelling in the right side of face without any history of trauma or systemic diso...

Introduction: It is well-recognized that cells of the monocyte/macrophage lineage are capable of fusion to form multinucleated giant cells (MGCs). The presence of multinucleated giant cells on FNAC smears of breast lumps have been described only sporadically in the literature. As this is a common specimen in Cytopathology, knowledge of frequency of this variation can be valuable to cytopatholog...

STATEMENT OF THE PROBLEM Peripheral and central giant cell granuloma are two common benign lesions of the oral cavity. In spite of histopathological similarities, they have different clinical behaviors. Cathepsin D is a lysosomal enzyme which has different functions on the basis of protein and applied peptide cleavage. PURPOSE This research aimed to evaluate and compare the expression level o...

Introduction: Multinucleated giant cells are often encountered in oral lesions. An understanding of the histogenesis of these giant cells can give us an insight on the pathologic process in progress. Traditional classifications have placed little importance on the type or histogenesis of multinucleated giant cells in grouping these lesions. Objectives: (a) To classify giant cell lesions based o...

central giant cell granulomas (cgcgs) may manifest as radiolucencies anywhere in the mandible or maxilla. in rare cases, it can appear as a localized periradicular area and mimic an endodontic lesion. this case report presents an uncommon location of cgcg which was not accurately diagnosed nor timely treated. periodic follow ups of periapical radiolucencies after rct are necessary. dentists sho...

the b cell is a vital contributor to humoral immunity. the b cell-specific antigen cd20 is expressed during b cell development, starting at the pre-b cell level and persists through b cell differentiation, but is lost during terminal differentiation to plasma cells. rituximab is a monoclonal antibody that destroys both normal and malignant b cells that have cd20 on their surfaces and is therefo...

background: giant retroperitoneal uterine leiomyomas are uncommon. degenerative changes of a leiomyoma may lead to unusual presentation resulting in misdiagnosis preoperatively. the final diagnosis can be made either intraoperatively or histologically. case: we report a 45-year-old multiparous women presented with abdominal distension and fatigue for six months. abdominopelvic sonography and co...

introduction: giant cell lesions of the bone comprise a group of jaw bone pathologies. different pathogeneses such as reactive, vascular or neoplastic have been proposed for these lesions. in addition, differentiating between aggressive and nonaggressive central giant cell granuloma (cgcg) of the jaws based on histopathologic features is still impossible and due to different treatment protocols...

in view of the rapid expansion of contact lens amongst the users, new dimensions have been added to the domain of ophthalmology: giant papillay conjunctivitis, a disease caused by different kinds of contact lens, appears weeks or months after they are used, although some patients are struck years later. the predominant symptoms are increased awareness of lenses, ocular itching, blurred vision a...