The gastrointestinal (GI) microbiota is the collection of microbes which reside in the GI tract and represents the largest source of non-self antigens in the human body. The GI tract functions as a major immunological organ as it must maintain tolerance to commensal and dietary antigens while remaining responsive to pathogenic stimuli. If this balance is disrupted, inappropriate inflammatory pr...

BACKGROUND/AIMS In South Korea, health check-ups are readily accessible to the public. We aimed to compare the prevalence of upper gastrointestinal (GI) and lower GI diseases in Korean Americans and native Koreans to determine differences and risk factors. METHODS In total, 1,942 subjects who visited Gangnam Severance Hospital from July 2008 to November 2010 for a health check-up were enrolle...

Oral delivery is the preferred route of drug administration due to patient compliance and convenience. Despite this, nanomedicines have so far primarily been developed for parenteral route. Inorganic nanoparticles hold great promise as theranostics oral delivery. This gaining importance especially local treatment gastrointestinal (GI) diseases. However, successful inorganic challenged by comple...

Clinicopathologic information of gastrointestinal (GI) lymphoma in Southeast Asia is lacking. A retrospective analysis of 120 cases of GI lymphoma in Thailand diagnosed at Siriraj Hospital based on WHO classification was performed. All were non-Hodgkin lymphoma (NHL). The peak age was in the sixth and seventh decades; a slight male preponderance was observed. Sites of involvement included stoma...

Neuroplasticity is an inherent feature of the enteric nervous system and gastrointestinal (GI) innervation under pathological conditions. However, the pathophysiological role of neuroplasticity in GI disorders remains unknown. Novel experimental models which allow simulation and modulation of GI neuroplasticity may enable enhanced appreciation of the contribution of neuroplasticity in particula...

Advanced gastrointestinal (GI) malignancies are varied in presentation, prognosis, and treatment options. With the exception of resectable recurrent colorectal cancer, metastatic GI malignancies are incurable. Cytotoxic chemotherapies have been the mainstay of therapy for decades but limited extension of survival or clinical benefit has been achieved in non-colorectal GI cancers. There has been...

The use of cyclooxygenase (COX-1)–sparing agents has revolutionized the treatment of rheumatic diseases. Because of the significant safety advantages of these drugs, patients at high risk for gastrointestinal (GI) side effects from using traditional nonsteroidal anti-inflammatory drugs (NSAIDs) can now achieve pain relief with a lower risk of GI adverse events. However, the costs of these drugs...

background: crohn’s disease is an inflammatory bowel disease that can affect any part of the gastrointestinal (gi) tract including the mouth. bowel symptoms are predominant. oral involvement may precede the gi symptoms. this case report presents a patient affected by crohn’s disease with oral onset. case presentation: we present a 30-year-old pregnant woman complaining of chronic, multiple, yel...

Objective: Recently, Red-Eared turtles are kept as pets in Iranian houses; however, because of lack of knowledge about their caring, they are in risk of lots of diseases.  Turtles of all ages should be fed with a diet that contains a wide variety of both animal and plant based items but they are usually fed by one item diet which may make gastrointestinal (GI) sickness. They are also several ba...

Implantable functional electrical stimulation (IFES) has demonstrated its effectiveness as an alternative treatment option for diseases incurable pharmaceutically (e.g., retinal prosthesis, cochlear implant, spinal cord implant for pain relief). However, the development of IFES for gastrointestinal (GI) tract modulation is still limited due to the poorly understood GI neural network (gut–brain ...