BACKGROUND Acylated ghrelin, biologically active form of ghrelin, activates growth hormone (GH) secretagogue receptor 1a and play a role in regulating of energy balance. The purpose of this study was to survey relationships between acylated ghrelin with GH, insulin resistance, lipid profile, and cardio respiratory function in lean and obese men. METHODS Nineteen obese men (body mass index 31....

Introduction: The objectives of our work were to compare the serum concentrations lipid parameters,insulin, resistin, ghrelin, zinc and magnesium between two groups men with obese type 2 diabetes a control group study possible correlations these differentparameters. Material methods: This was monocentric case-control during period 19 October 2015 18 November 2015. It included biological paramet...

Type 2 diabetes is characterized by insulin resistance and mitochondrial dysfunction in classical target tissues such as muscle, fat, and liver. Using a murine model of type 2 diabetes, we show that there is hypothalamic insulin resistance and mitochondrial dysfunction due to downregulation of the mitochondrial chaperone HSP60. HSP60 reduction in obese, diabetic mice was due to a lack of proper...

We recently described a connection between androgens and ghrelin in women affected by the polycystic ovary syndrome. To further investigate the interaction between sex steroids and ghrelin, we investigated circulating ghrelin levels in a group of hypogonadal men before and after therapeutic intervention aiming at normalization low testosterone (T) concentrations. Seven hypogonadal men were comp...

Objective: Appetite is affected by the metabolic profile, infections and nutritional shape in domestic animals. Regulation of appetite involves many complex physiological processes. Ghrelin well known appetite-enhancing hormone. The also managed lateral hypothalamus. On other hand, ventromedial nucleus most commonly associated with satiety. Brotizolam, member 1,4-benzodiazepines derivative, blo...

AIM Obesity and insulin resistance are associated with nonalcoholic fatty liver disease (NAFLD). It was recently reported that the ratio between levels of ghrelin and obestatin is also associated with obesity and insulin resistance. We investigated the association between the ghrelin/obestatin ratio and NAFLD. METHODS This cross-sectional study included 98 subjects (51 NAFLD patients and 47 c...

The purpose of this study was to investigate the relationship between birth weight and appetite related hormones, insulin resistance, and antioxidant status in overweight children aged 9-10 years. Thirty-four healthy overweight children (18 boys, 16 girls) were evaluated with respect to anthropometric measurement, lipid profiles, leptin, ghrelin, glucose, insulin, C-peptide, lipid soluble vitam...

Weight reduction after gastric bypass surgery has been attributed to a decrease of the orexigenic peptide ghrelin, which may be regulated by insulin and leptin. This study examined effects of long-term weight loss after laparoscopical adjustable gastric banding on plasma ghrelin and leptin concentrations and their relationship with insulin action. Severely obese patients (15 women, three men, 3...

CONTEXT Metabolic syndrome shows clustered metabolic abnormalities with major roles for insulin resistance and obesity. Ghrelin is a gastric hormone whose total plasma concentration (T-Ghr) is associated positively with insulin sensitivity and is reduced in obesity. Ghrelin circulates in acylated (A-Ghr) and desacylated (D-Ghr) forms, but their potential differential associations with insulin r...

Ghrelin is a circulating orexigenic hormone which is implicated in both the short-term control of food intake at single meals and in long-term body weight regulation. Due to the potent orexigenic action of this hormone, it would be expected that obese subjects would show elevated ghrelin levels that could contribute to pathogenesis of obesity. However, it was observed that ghrelin is downregula...