An important function of all organisms is to ensure that their genetic material remains intact and unaltered through generations. This is an extremely challenging task since the cell's DNA is constantly under assault by endogenous and environmental agents. To protect against this, cells have evolved effective mechanisms to recognize DNA damage, signal its presence, and mediate its repair. While...

A single server queue with Bernoulli vacation has been considered. In addition the admission to queue is based on a Bernoulli process and the server gives two type of services. For this model the probability generating function for the number of customers in the queue at different server's state are obtained using supplementary variable technique. Some performance measures are calculated. Some ...

In this paper we consider a queuing system in which the service times of customers are independent and identically distributed random variables, the arrival process is stationary and has the property of orderliness, and the queue discipline is arbitrary. For this queuing system we obtain the steady state second moment of the queue size in terms of the stationary waiting time distribution of a s...

Fog Computing is a new paradigm that has been proposed by CISCO to take full advantage of the ever growing computational capacity of the near-user or edge devices (e.g., wireless gateways and sensors). The paradigm proposes an architecture that enables the devices to host functionality of various usercentric services. While the prospects of Fog Computing promise numerous advantages, development...

The acquisition of genotoxin-induced mutations in the mammalian germline is detrimental to the stable transfer of genomic information. In somatic cells, nucleotide excision repair (NER) is a major pathway to counteract the mutagenic effects of DNA damage. Two NER subpathways have been identified, global genome repair (GGR) and transcription-coupled repair (TCR). In contrast to somatic cells, li...

Human cells lacking functional p53 exhibit a partial deficiency in nucleotide excision repair (NER), the pathway for repair of UV-induced DNA damage. The global genomic repair (GGR) subpathway of NER, but not transcription-coupled repair (TCR), is mainly affected by p53 loss or inactivation. We have utilized mouse embryo fibroblasts (MEFs) lacking p53 genes or downstream effector genes of the p...