Glomerular filtration rate (GFR) estimating equations, infrequently used just a decade ago, are now recommended for the evaluation of kidney function for routine clinical care and are routinely reported by the vast majority of clinical laboratories (1 ). Current clinical guidelines recommend estimated GFR (eGFR) based on serum creatinine (eGFRCr) as the initial diagnostic test, and either a mea...

Knowledge of glomerular filtration rate (GFR) is required to detect and follow impairment of renal function, to allow correct dosage of drugs cleared by the kidneys, and for the use of nephrotoxic contrast media. Correct determination of GFR requires invasive techniques, which are expensive, slow and not risk-free. Therefore, GFR-prediction equations based solely upon cystatin C or creatinine a...

Detecting quantity trait locus (QTLs) and elite alleles that are associated with grain-filling rate (GFR) in rice is essential for promoting the utilization of hybrid japonica rice and improving rice yield. Ninety-five varieties including 58 landraces and 37 elite varieties from the core germplasm collection were genotyped with 263 simple sequence repeat (SSR) markers. The GFR of the 95 varieti...

OBJECTIVE The aim of this study was to compare cystatin C versus creatinine as a marker for acute kidney injury in patients submitted to cardiac surgery with cardiopulmonary bypass. METHODS Fifty consecutive patients submitted to coronary artery bypass grafting were studied. Renal function was evaluated by serum cystatin C and creatinine. Blood samples were obtained from each patient at three...

BACKGROUND Symmetric dimethylarginine (SDMA) is a small molecule formed by methylation of arginine, and released into blood during protein degradation. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate (GFR). OBJECTIVES To validate an assay for SDMA measurement, determine stability of SDMA in blood, and compare SDMA with serum c...

BACKGROUND Renal function is an important risk marker for morbidity and mortality in chronic heart failure (CHF) and is often estimated with the use of creatinine-based formulas. However, these formulas have never been validated in a wide range of CHF patients. We validated 3 commonly used formulas estimating glomerular filtration rate (GFR) with true GFR in CHF patients. Furthermore, we compar...

Assessment of glomerular filtration rate (GFR) is essential for clinical practice. GFR is difficult to measure [measured GFR (mGFR)]; instead it is estimated [estimated GFR (eGFR)] by use of the serum concentration of endogenous filtration markers. However, all endogenous filtration markers are affected by factors other than GFR (non-GFR determinants), including generation, renal tubular reabso...

BACKGROUND This study examines whether the serum concentration of cystatin C (Cys C) correlates with the severity of coronary artery disease (CAD) and whether it provides additional information on the risk for CAD in patients without chronic kidney disease (CKD) estimated by the creatinine-based glomerular filtration rate (GFR). METHODS AND RESULTS The relationship between serum Cys C and the...

Dynamic contrast-enhanced MR renography, analyzed with appropriate tracer kinetic models [1], is a promising technique for the non-invasive assessment of glomerular filtration rate (GFR). Dual-injection measurements, such as before and after administration of an angiotensin-convertingenzyme (ACE) inhibitor, have been proposed as an improved diagnostic marker of renovascular disease [2]. Technic...