BACKGROUND Gestational trophoblastic neoplasia (GTN) disease is excessive and inappropriate proliferation of trophoblast after termination of the pregnancy. Many attempts have been made to improve follow-up procedures, but no studies have evaluated Human Chorionic Gonadotrophin (HCG) as a post treatment indicator. Thus we aimed to know β-HCG variability in post treatment pregnancies. METHODS ...

Background: Gestational trophoblastic neoplasia (GTN) originates from placental trophoblast and is a highly chemosensitive and curable gynecologic malignancy. The present study was conducted to evaluate the effectiveness and safety of EMA/EP (etoposide, methotrexate, actinomycin-D, etoposide, and cisplatin) regimen in the treatment of high-risk GTN as well as patients’ outcome.  &nb...

Gestational trophoblastic disease includes hydatidiform mole (complete and partial) and gestational trophoblastic neoplasia (invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor). The epidemiology, pathology, clinical presentation, and diagnosis of each of these trophoblastic disease variants are discussed. Particular emphasis is given to manag...

Introduction. Invasive mole, a form of gestational trophoblastic neoplasia (GTN), is defined as penetration molar tissue into the myometrium and/or presence extra-uterine metastases. An invasive mole arising from complete hydatidiform more common than an partial mole. Dilatation and uterine evacuation curettage (D&E/C) first step in managing pregnancy. Uterine perforation most serious compl...

The authors present the computed tomographic findings in a patient with malignant gestational trophoblastic neoplasia. No similar case has been described on computed tomography. The interesting aspects of the case and a brief review of this clinical entity is discussed. Pelvic computed tomography Ovary Malignant gestational trophoblastic neoplasia Theta-lutein cysts

Introduction: Gestational trophoblastic neoplasia (GTN), is recognized as the most curable gynaecologic malignancy. However, many cases are resistant to first line chemotherapy. Objective: The aim of the study is to report our 5 years experience in the management of GTN cases with special stress on the chemo-resistant cases. Methods: The study was performed through reviewing the records of 51 p...

OBJECTIVE To investigate the slope of linear regression of postevacuation serum hCG as an independent risk factor for postmolar gestational trophoblastic neoplasia (GTN). DESIGN Multicenter retrospective cohort study. SETTING Academic referral health care centers. PATIENT(S) All subjects with confirmed hydatidiform mole and at least four measurements of β-hCG titer. INTERVENTION(S) None...