normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 there are a few case series of giant cell tumor (gct) in the spine and sacrum. gct in the thoracic vertebrae is even more exceptional in the medical literature. in this article we report a gct in a 25-year-old male who presented with progressive back pain and dyspnea. on contrast-enhanced multidetector computer tomography,...

BACKGROUND Neuroendocine carcinoma of the gynecologic tract is rare and poses a significant clinical challenge because of tumor heterogeneity and lack of standardized guidelines for treatment. Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. Ovotesticular disorder of sexual development occurs in fewer than 10% of all disorders of...

chloroma or granulocytic sarcoma (gs) is a malignant neoplasm of myeloid lineage that occur in a variety of anatomic sites other than the bone marrow including soft tissue, bone, lymph node, nasal fossa, skin and sometime in the orbit. in the subconjunctiva it is rarely reported. a 4-year-old girl with a history of treated acute myelogenous leukemia was referred to farabi eye hospital, tehran, ...

Objective Genetic and morphologic similarities between mouse embryonic stem cell (ESCs) and Primordial Germ Cell (PGCs) make it difficult to distinguish the two cell types in in vitro differentiation. Using the expression of specific markers of germ cells that are not expressed or expressed at low levels in ESCs, can help recognizing in vitro differentiated cells MaterialsAndMethods In this stu...

Background The piwi family genes are highly conserved during evolution and play a crucial role in stem cell self-renewal, gametogenesis, and RNA interference in diverse organisms ranging from Arabidopsis to humans. Piwil2, also known as Hili, is one of the four human homologues of piwi. Piwil2 was found in germ cells of adult testis, suggesting that this gene functions in spermatogonial stem ce...

  Objective(s): Sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. The present study was designed to analyze the effect of Sertoli cells in differentiation of mouse embryonic stem cells (mESCs) to germ cells.   Materials and Methods: A fusion construct composed of a Stra8 gene promoter and the coding region of enhanced green fluorescence p...

Ovarian yolk sac tumor (YST) is a malignant germ cell tumor generally arising in young females and occurs very rarely after menopause. We describe a case of ovarian YST in a 60-year-old postmenopausal woman. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and retroperitoneal lymphadenectomy for a right ovarian tumor 10 cm in diameter. Microscopic examination...

Background: Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficult...