نتایج جستجو برای: genetically significant dose
تعداد نتایج: 1511435 فیلتر نتایج به سال:
The “Linear No Threshold” hypothesis, used in all radiation protection practices, assumes that all doses, no matter how low, increase risk. However, in human and other mammalian cells, low doses of low LET radiation such as gamma and X-rays induce an adaptive response that protects against both radiation-induced and spontaneous risk. An in vivo test of the hypothesis in mice showed that a 100-m...
Genetically engineered viruses and viral genes inserted into retroviral vectors are increasingly being considered for experimental therapy of brain tumors. A primary target of these viruses and vectors is human gliomas, the most frequently occurring primary human brain tumor. To investigate the potential of genetically engineered herpes simplex viruses (HSVs) in the therapy of these tumors, we ...
Introdution: Presence of mentally retarded children as a source of pressure can jeopardize the general health of parents, especially mothers. The range of effect depends on the recognitive evaluation and the individual. The aim of this study was to investigate the effect of coping-therapy on mental health of mothers with genetically and non genetically mentally retarded children referring to Ya...
ABSTRACT: Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur situations of overdose and/or malnutrition, young animals, and genetically sensitive breeds. We describe the intoxication by doramectin malnourished 15-month-old cattle that received 1.6 times recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, st...
Warfarin dosing is correlated with polymorphisms in vitamin K epoxide reductase complex 1 (VKORC1) and the cytochrome P450 2C9 (CYP2C9) genes. Recently, the FDA revised warfarin labeling to raise physician awareness about these genetic effects. Randomized clinical trials are underway to test genetically based dosing algorithms. It is thus important to determine whether common single nucleotide ...
Pharmacokinetic and biodistribution studies were conducted in rats on a novel serine protease inhibitor, LEX 032, that was radiolabeled with 131I by the Bolton-Hunter reagent. LEX 032, a genetically engineered recombinant human nonglycosylated serpin, has been shown to have antiinflammatory properties in a number of animal models of inflammation and reperfusion injury. When 131I-LEX 032 was inj...
Discovery of x-ray and using of it for medical imaging have produced tremendous outcomes for diagnosis and treatment of diseases. More than 10 million diagnostic radiological procedures and 100,000 nuclear medicine exams are being performed daily around the world. According to the national commission on radiological protection and measurements (NCRP)-report 160, medical x-ray is contribute to a...
Effective and simple delivery of DNA vaccines remains a key to successful clinical applications. Previously, we developed novel class vaccines, sometimes called iDNA, which encodes the whole live-attenuated vaccine viruses. Compared standard vaccine, an iDNA required low dose launch in vitro or vivo . The goal this pilot study was investigate if encoding Venezuelan equine encephalitis virus (VE...
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