We show that if a class of modules is closed under pure quotients, then it is precovering if and only if it is covering, and this happens if and only if it is closed under direct sums. This is inspired by a dual result by Rada and Saorín. We also show that if a class of modules contains the ground ring and is closed under extensions, direct sums, pure submodules, and pure quotients, then it for...

Isolation of DNA from formalin-fixed, paraffin-embedded (FFPE) tissue remains a laborious task for clinical laboratories and researchers who need to screen several samples for genetic variants. The objective of this study was to evaluate DNA isolation methods from FFPE tissues and to choose an efficient method with less hands-on time to obtain DNA of optimum concentration and purity for use in ...

Plants have too long been ignored as useful screening and monitoring systems of environmental mutagens. However, there are about a dozen reliable, some even unique, plant genetic systems that can increase the scope and effectiveness of chemical and physical mutagen screening and monitoring procedures. Some of these should be included in the Tier II tests. Moreover, plants are the only systems n...

BACKGROUND Chloroplast genomes supply valuable genetic information for evolutionary and functional studies in plants. The past five years have witnessed a dramatic increase in the number of completely sequenced chloroplast genomes with the application of second-generation sequencing technology in plastid genome sequencing projects. However, cost-effective high-throughput chloroplast DNA (cpDNA)...

OBJECTIVES Amphotericin B (AmB) is a drug of choice for treatment of disseminated fungal infections, but its use is often associated with severe adverse effects. Our observation that generic formulations of AmB contain multiple polyene components led us to propose that removal of other polyenes would yield a high purity AmB (AmBHP) with an improved therapeutic index. METHODS To test that prem...

Adámek and Sousa recently solved the problem of characterizing the subcategories K of a locally λ-presentable category C which are λ-orthogonal in C, using their concept of Kλ-pure morphism. We strenghten the latter definition, in order to obtain a characterization of the classes defined by orthogonality with respect to λ-presentable morphisms (where f :A B is called λ-presentable if it is a λ-...

We consider smooth completion of algebraic manifolds. Having some information about its singular completions or about completions of its images we prove purity of cohohomology of the set at infinity. We deduce also some topological properties. The work is based on the study of perverse direct images for algebraic maps.

BACKGROUND Induced pluripotent stem cells (iPSC) can be differentiated into cardiomyocytes and represent a possible autologous cell source for myocardial repair. We analyzed the engraftment and functional effects of murine iPSC-derived cardiomyocytes (iPSC-CMs) in a murine model of myocardial infarction. METHODS AND RESULTS To maximize cardiomyocyte yield and purity a genetic purification pro...

Many mathematicians have sought ‘pure’ proofs of theorems. There are different takes on what a ‘pure’ proof is, though, and it’s important to be clear on their differences, because they can easily be conflated. In this paper I want to distinguish between two of them. I want to begin with a classical formulation of purity, due to Hilbert: In modern mathematics one strives to preserve the purity ...