It has been shown that the acetamido methyl protons of N-acetyl-D-glucosamine undergo a chemical shift to higher fields in their proton magnetic resonance spectrum when the inhibitor is bound to lysozyme. The observed chemical shift in the presence of the enzyme is different for the CP and /3-anomeric forms of Z-acetamido-Z-deoxy-D-glucopyranose indicating either a difference in the afhnity of ...

Ab initio MO calculations were carried out at the MP4/6-311++G(3df,3pd)//MP2/6-311++G(3df,3pd) level to investigate the conformational Gibbs energy of a series of methyl ethers CH(3)O-CH(2)-X (X=OH, OCH(3), F, Cl, Br, CN, C triple bond CH, C(6)H(5), CHO). It was found that the Gibbs energy of the gauche conformers is lower in every case than that of the corresponding anti conformers. In the mor...

Some time ago we reported the oxidation of 2,3-unsaturated hexopyranosides and 2-Cmethylene glycosides with hydrogen peroxide in the presence of molybdenum trioxide catalyst to give the corresponding anomeric hydroperoxides 1-5. Relatively stable hydroperoxides 1-5 were used for enantioselective oxidation of prochiral alcohols and sulfides in the presence of Ti(OiPr)4 with stereoselectivities v...

Glycoside bond formation generally requires activation of the sugar at the anomeric center. To this end, anomeric oxygen exchange reactions, resulting in the Koenigs±Knorr method and variations or, alternatively, activation through retention of the anomeric oxygen, resulting in the trichloroacetimidate method and in the phosphite method, have been proposed. The successful application of the tri...

The synthesis of 1-thiotrehaloses and thioglycals by a directed copper-catalyzed dehydrogenative C?H thiolation the pseudo-anomeric bond glycals is described. use aminoquinoline-containing as well thiosugars or thiols coupling partners led to library thioglycosides in moderate good yields.

Studying changes in brain activation according to the valence of emotion-inducing stimuli is essential in the research on emotions. Due to the ecological potential of virtual reality, it is also important to examine whether brain activation in response to emotional stimuli can be modulated by the three-dimensional (3D) properties of the images. This study uses functional Magnetic Resonance Imag...

This paper studies the sensitivity of random effects estimators in the one-way error component regression model. Maddala and Mount (1973) give simulation evidence that in random effects models the properties of the feasible GLS estimator β̂ are not affected by the choice of the first-step estimator θ̄ used for the covariance matrix. Taylor (1980) gives a theoretical example of this effect. This p...

Binomial data are often generated in split-plot experimental designs in agricultural, biological, and environmental research. Modeling non-normality and random effects are the two major challenges in analyzing binomial data in split-plot designs. In this study, seven statistical methods for testing whole-plot and subplot treatment effects using mixed, generalized linear, or generalized linear m...

1 In this paper, the necessity for treating intra-household correlation is investigated by analyzing 2 two travel behavior indices, i.e. travel time and travel distance, for three important travel motives 3 (commuting, shopping, and leisure). Data stemming from the 2010 Belgian National Household 4 Travel Survey are used in the analysis. Two model approaches that accommodate for intra5 househol...

We present the hglm package for fitting hierarchical generalized linear models. It can be used for linear mixed models and generalized linear mixed models with random effects for a variety of links and a variety of distributions for both the outcomes and the random effects. Fixed effects can also be fitted in the dispersion part of the model.