objective: bipolar i disorder is a common disorder with a complex etiology. a genetic approach is gaining increasing importance in this disorder. the dysbindin gene, located at 6p22.3 is considered a susceptibility gene for schizophrenia. certain genotypes of dysbindin are thought to be associated with other psychoses such as bipolar disorders. this study intends to assess the association in pr...

staphylococcus aureus carrying pvl gene remain major health problem associated with highly virulent infections. characterization of such gene is important to know the impact and the functional significance of nucleotide variations. pcr and standard sequencing were performed for twelve sudanese strains from different sources. protein structures prediction, modeling and physiochemical analysis we...

Mapping the polymorphisms responsible for variation in gene expression, known as Expression Quantitative Trait Loci (eQTL), is a common strategy for investigating the molecular basis of disease. Despite numerous eQTL studies, the relationship between the explanatory power of variants on gene expression versus their power to explain ultimate phenotypes remains to be clarified. We addressed this ...

Phylogenetic relationships and genetic variation between two Iranian sheep breeds were analyzed using cytochrome b (cyt-b) gene sequences. The genomic DNA was isolated by salting out method and amplified cytochrome b gene using polymerase chain reaction restriction (PCR) method with a pair of primer. A partial sequence of cyt-b gene of Iranian sheep is 780 bp and contained 13 variable sites and...

Sixteen avian influenza (AI) H9N2 viruses were isolated from disease outbreaks in different parts of Iranduring (1998–2001). These AI isolates were used for pathogenicity, haemagglutinin (HA) gene variation andphylogenetic analysis. Results in both pathogenicity tests and HA gene cleavage site sequence detectionrepresented a non-highly pathogenic feature for all Iranian AI isolates studied. The...

background: baculoviral inhibitor of apoptosis repeat-containing 5 (birc5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. the copy number of birc5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. methods: forty tumor tiss...