نتایج جستجو برای: gene silencing
تعداد نتایج: 1153673 فیلتر نتایج به سال:
Purpose: To determine the effect of targeted silencing CDX2 with siRNA on vincristine-induced inhibition proliferation and apoptosis induction in leukemia K562 cells.
 Methods: cells were divided into untreated group, vincristine blank CDX2-siRNA group. The expression gene after transfection was determined by reverse-transcription-polymerase chain reaction (RT-PCR) immunoblotting, while MT...
Background and Objective: Transcription factors (TF) and microRNAs, are the largest families of transacting gene regulatory molecules in multicellular organisms. Our goal was to examine the effect of aerobic running on the expression of miR-124 and RE1-silencing TF in the hippocampus of adult male Wistar rats. Materials and Methods: A total of twelve 8-week-old adult male Wistar rats with a mea...
Background & Aims: The use of siRNA to silence gene expression is increasingly expanding today. The aim of this study is to bioinformatically and experimentally investigate the inhibition of the HMGA2 gene and its corresponding effects on downstream genes expression rate in MDA-MB-231 cancer cell treated by shRNA and siRNA specific to HMGA2. Materials & Methods: To perform this bioinformatic a...
Twenty-five years ago the field of eukaryotic gene regulation was in its infancy. Paradigms driving experiments came primarily from work with prokaryotes and the phage that infected them (12). These paradigms, pioneered by Jacob and Monod, were that genes contained promoter sequences to which RNA polymerase bound and cis-acting sequences to which geneor pathway-specific trans-acting factors bou...
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