Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1b-driven neuroinflammation in the pathogenesis of diabetic retinopathy. IL-1b is well known for its role in the induction and, through autostimulation, amplification of neuroinflammation. Upregulation of IL-1b has been consistently detected in the diabetic retina; however, the mechanisms and cellula...

Introduction: Helicobacter pylori (H. pylori) infection has remained as a global health problem. Animal studies demonstrated the role of H. pylori oipA gene in the development of gastric cancer. The aim of this study was the cloning and expression of Helicobacter pylori oipA gene in a bicistronic vector harboring mice IL-18 gene. Materials and methods: The target gene encoding oipA was amp...

Recent studies report that individuals with polymorphisms in the genes encode for interleukin (IL)-1α and IL-1β (IL-1A IL1B, respectively) IL-1 receptor antagonist (IL-1RN) may be more susceptible developing peri-implantitis. Therefore, current systematic review evaluates what is reported about role of genetics, specifically single nucleotide (SNP) on variable number tandem repeats (VNTR) IL-1R...

BACKGROUND AND AIMS Recent studies linked cytokine gene polymorphisms to H pylori related gastric cancer development. The current study evaluated the role of cytokine gene polymorphisms for mucosal cytokine expression, the gastric inflammatory response, and bacterial colonisation during H pylori infection. PATIENTS AND METHODS In 207 H pylori infected patients with chronic gastritis, polymorp...

Background: Interleukin (IL)-23 and IL-27 are two IL-12-related cytokines which their function may dramatically influence the inflammatory response to tumor development. IL-12 and IL-27 seem to have antagonistic roles with IL-23 in tumor site. In this study, IL-23 and IL-27 mRNA expressions were analyzed in peripheral blood of patients with breast cancer and healthy volunteers using quantitativ...

Background: The inflammatory process in chronic obstructive pulmonary disease (COPD) is characterised by the presence of neutrophils in the lung that are able to synthesise de novo several inflammatory mediators. The local chronic persistent inflammatory response is accompanied by systemic effects such as cytokine induced priming of peripheral leucocytes and muscle wasting. The preactivation or...

Background & Aims: Endurance training has an important role in the prevention and adjuvant therapy of breast cancer. The aim of the present study was to investigate the role of endurance training on miR- 155 expression, signal transducer and activator of transcription-3 (STAT3) gene expression, and interleukin 6 (IL-6) protein in breast cancer tumor in mice. Methods: In this study, 16 female Ba...

introduction: helicobacter pylori (h. pylori) infection has remained as a global health problem. animal studies demonstrated the role of h. pylori oipa gene in the development of gastric cancer. the aim of this study was the cloning and expression of helicobacter pylori oipa gene in a bicistronic vector harboring mice il-18 gene. materials and methods: the target gene encoding oipa was amplifie...

In atheroma, T cell–derived interferon-g (INF-g) stimulates endothelial cells and facilitates recruitment of monocytes. We investigated potential mechanisms by which these interactions could contribute to local and systemic inflammatory responses. Specifically, we analyzed the expression of interleukin (IL)-1b and IL-6 in both cell types after coculture, the relevant adhesion molecules in this ...