BACKGROUND The isoflavone genistein (GEN) is found in soy (Glycine max) and red clover (Trifolium pratense). The estrogenic activity of GEN is known, and it is widely advertised as a phytoestrogen useful in alleviating climacteric complaints and other postmenopausal disorders. Knowledge of effects of long-term administration of GEN in laboratory animals is scarce, and effects in the uterus and ...

Agraecia Audinet-Serville, the type-genus of Agraeciini, comprises fifteen species names: thirteen used for extant species, one junior synonym, and one fossil. The species are morphologically very dissimilar, and were collected and described from different localities of the world. The genus was reassessed based on recently collected specimens from Brazil and Argentina as well as museum specimen...

Objectives: Free radicals generation, inflammation, and nitric oxide (NO) modulation are involved in indomethacin (IND)-induced gastric ulcers. Most of the drugs used for the treatment of gastric ulcer have various side effects. Genistein (GEN), the natural isoflavones isolated from soya bean has an antioxidant, anti-inflammatory, and NO modulating activity. These properties could make GEN a pr...

Neonatal exposure to genistein (GEN), an isoflavone abundant in soy, favorably modulates bone mineral density (BMD) and bone strength in mice at adulthood. The study objective was to determine whether early exposure to a combination of the soy isoflavones daidzein (DAI) and GEN that naturally exists in soy protein-based infant formula results in greater benefits to bone at adulthood than either...

The objective of this study was to determine if genistein (GEN) modulation of the immune responses might contribute to the increased host resistances to tumors. A time-course study was performed in adult female B6C3F1 mice that had been exposed to GEN for 1-4 weeks at the dose level of 20 mg/kg by gavage. A significant increase in ex vivo cytotoxic T lymphocyte (CTL) activity was observed in th...

We adopted an in vitro infective endocarditis model (IVIEM) to compare the efficacy of vancomycin (VAN), arbekacin (ABK), and gentamicin (GEN) alone or in combination. Using two strains of clinically isolated methicillin-resistant Staphylococcus aureus, one GEN susceptible (GS171) and one GEN resistant (GR153), fibrin clots were prepared and suspended in the IVIEM. Antibiotics were given as bol...

background: the aim of this study was to examine the renoprotective effect of hydro alcoholic sage (salvia officinalis: so) leaves extract against gentamicin-induced nephrotoxicity in rats. methods: in this experimental study forty male sprague dawley rats weighing 200-300 g were randomly divided into 5 groups; (1) the rats without treatment (control), (2) intraperitoneally injected with normal...

Genistein (GEN), a soy isoflavone, stimulates growth of estrogen-dependent human tumor cells (MCF-7) in a preclinical mouse model for postmenopausal breast cancer. Antiestrogens and aromatase inhibitors are frontline therapies for estrogen-dependent breast cancer. We have demonstrated that dietary GEN can negate the inhibitory effect of tamoxifen. In this study, we evaluated the interaction of ...

E nglish teaching professionals working with children in primary school, adolescents in secondary school, or adults at university know that learners nowadays think and behave differently than those from previous generations. These students were born into a world of information technology; they prefer to multitask rather than focus on one thing at a time, and they can be more attracted to the id...