نتایج جستجو برای: gem tv
تعداد نتایج: 20064 فیلتر نتایج به سال:
Treating breast cancer brain metastases (BCBMs) is challenging. Na+/I- symporter (NIS) expression in BCBMs would permit their selective targeting with radioiodide (131I-). We show impressive enhancement of tumor response by combining131I- with gemcitabine (GEM), a cytotoxic radiosensitizer. Nude mice mammary fat-pad (MFP) tumors and BCBMs were generated with braintropic MDA-MB-231Br cells trans...
Despite attempts to use multiple drug combinations that include gemcitabine (GEM), there is very little evidence that these combination regimens are superior to the single use of this agent. We therefore investigated the suppressive effect of the combination of systemically administered GEM and locally administered interleukin-2 (IL-2) on liver metastasis in pancreatic cancer. Tumor-bearing mic...
In order to investigate the spatial and temporal variability of atmospheric mercury (Hg) in Chongqing, China, gaseous elemental mercury (GEM) was measured from August 2006 to September 2007, using Lumex multifunctional mercury analyzer RA-915(+) (Lumex Ltd., Russia). The mean GEM concentration was 6.74 +/- 0.37 ng m(-3) in Chongqing, much higher than the accepted global background values (1.5-2...
Purpose: Investigate the efficacy and pharmacodynamic effects of MK-1775, a potent Wee1 inhibitor, in both monotherapy and in combination with gemcitabine (GEM) using a panel of p53-deficient and p53 wild-type human pancreatic cancer xenografts. Experimental Design: Nine individual patient-derived pancreatic cancer xenografts (6 with p53-deficient and 3 with p53 wild-type status) from the PancX...
BACKGROUND This phase III trial compared the efficacy and safety of gemcitabine plus capecitabine (GemCap) versus single-agent gemcitabine (Gem) in advanced pancreatic cancer as first-line chemotherapy. METHODS A total of 214 advanced pancreatic cancer patients were enrolled from 16 hospitals in South Korea between 2007 and 2011. Patients were randomly assigned to receive GemCap (oral capecit...
The purpose of this study was to increase our understanding of the gaseous elemental mercury (GEM, Hg◦) fluxes between the atmosphere and soils. Moreover, we wanted to quantify the annual GEM flux, identify the controls, and compare the GEM flux to annual rates of gaseous oxidized mercury (GOM) dry deposition and wet deposition of total mercury. We measured GEM fluxes using the modified Bowen r...
Although gemcitabine (GEM) is widely used in the treatment of pancreatic cancers, the molecular mechanisms that underlie its anti-tumor effects are not fully understood. To clarify the anti-tumor mechanism(s) of GEM, we studied a human pancreatic cancer cell line, YPK-1, that showed a 50% inhibitory concentration (IC50) of GEM of 6.3 x 10(-3) microg/ml after 72 h of exposure. Cell proliferation...
As documented with examples in this special issue of Ambio, the Greenland Ecosystem Monitoring (GEM) Programme in its first 20 years has focused on both detailed and very comprehensive studies of specific ecosystems in order to monitor and understand ecosystem patterns and processes. An international review of GEM conducted in 2015 praised the programme for its comprehensiveness, but also saw a...
Bladder cancer is a common malignancy for which regional or metastatic disease is identified at diagnosis. The aim of this study was to determine whether tamoxifen (Tam), an estrogen receptor (ER) antagonist, can sensitize bladder cancer cell lines to gemcitabine (Gem) chemotherapy. ERα and ERβ protein levels were determined in each cell line using western blot analysis. The TCC-Sup, 5637, and ...
Individual members of the RGK family of Ras-related GTPases, which comprise Rad, Gem/Kir, Rem and Rem2, have been implicated in important functions such as the regulation of voltage-gated calcium channel activity and remodeling of cell shape. The GTPase Kir/Gem inhibits the activity of calcium channels by interacting with the beta-subunit and also regulates cytoskeleton dynamics by inhibiting t...
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