We have recently demonstrated that inhibition of Rho GTPase with Clostridium difficile toxin B, or with Clostridium botulinum C3 toxin, causes actin depolymerization and translocation of aquaporin 2 (AQP2) in renal CD8 cells in the absence of hormonal stimulation. Here we demonstrate that Rho inhibition is part of the signal transduction cascade activated by vasopressin leading to AQP2 insertio...

This paper presents three systems submitted to the German Dialect Identification (GDI) task at the VarDial Evaluation Campaign 2017. The task consists of training models to identify the dialect of SwissGerman speech transcripts. The dialects included in the GDI dataset are Basel, Bern, Lucerne, and Zurich. The three systems we submitted are based on: a plurality ensemble, a mean probability ens...

The role of GDP dissociation inhibitor (GDI) protein in regulation of Rab cycle in Leishmania is not known. Here, we have cloned and characterized the functions of GDI homologue in vivo in Leishmania. Our results have shown that LdGDI:WT along with GDP removes the Rab5 from purified endosomes and inhibits the homotypic fusion between early endosomes. Whereas, LdGDI:R239A, a dominant negative mu...

Normal somatic cells enter a state of irreversible proliferation arrest-designated cellular senescence, which is characterized by biochemical changes and a distinctive morphology. Cellular stresses, including oncogene activation, can lead to senescence. Consistent with an antioncogenic role in this process, the tumor suppressor pRb plays a critical role in senescence. Reexpression of pRb in hum...

Existing drought indices have been widely used to monitor meteorological drought and agricultural drought; however, few of them are focus on drought monitoring for grassland regions. This study presented a new drought index, the Grassland Drought Index (GDI), for monitoring drought conditions in global grassland regions. These regions are vital for the environment and human society but suscepti...

Corticosterone, themajor stress hormone, plays an important role in regulating neuronal functions of the limbic system, although the cellular targets and molecular mechanisms of corticosteroid signaling are largely unknown. Here we show that a short treatment of corticosterone significantly increases -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated synaptic transmis...

The Rho family of GTPases control actin organization during diverse cellular responses (migration, cytokinesis and endocytosis). Although the primary members of this family (RhoA, Rac and Cdc42) have different downstream effects on actin remodeling, the basic mechanism involves targeting to the plasma membrane and activation by GTP binding. Our hypothesis is that the details of GTPase cycling b...

OBJECTIVES It is well known that sex differences in analgesic prescription are not merely the logical result of greater prevalence of pain in women, since this therapeutic variability is related to factors such as educational level or social class. This study aims to analyse the relationship between analgesic prescription and gender development in different regions of Spain. METHODS Cross-sec...

Isolated adrenocorticotropin deficiency (IAD) is characterized by low or absent adrenocorticotropic hormone (ACTH) production. IAD is presumed to be caused in part by an autoimmune mechanism, and several lines of evidence have suggested the presence of anti-pituitary antibodies in IAD. However, the exact autoantigens remain unknown. The present study was designed to identify the autoantigen(s) ...

This paper gives the comparison of performance of full adder design in terms of area, power and delay in different logic styles. Full adder design achieves low power using the Transmission Gate logic compared to all other topologies such as Basic CMOS, Pass Transistor and GDI techniques but it make use of more number of transistors compared to GDI. GDI occupies less area compared to all other l...