giant cell tumors (gct) are benign tumors with potential for aggressive behavior and capacity to metastasize. although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. its histogenesis remains unclear. it is characterized by a proliferation of mononuclear stromal ce...

Granular Cell Tumors (GCTs) or Abrikossoffs tumors are ubiquitous lesions that currently assumed to arise from perineural Schwan cells. of the Breast (GCTBs) rare tumors, representing about 5 15 % all GCTs and 6,7 out 1000 cases breast neoplasms. They occur usually in premenopausal African-American women by large benign, even though extremely they can express malignant behavior coexist with les...

The receptor-activator of nuclear kappaB ligand (RANKL) signaling pathway plays an important role in the regulation of bone growth and mediates the formation and activation of osteoclasts. Osteoclasts are involved in significant bone resorption and destruction. Denosumab is a fully human monoclonal antibody against RANKL that specifically inhibits osteoclast differentiation and bone resorption....

  Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal ...

•This Clinical Practice Guideline provides key recommendations on the management of bone sarcomas.•Recommendations have been agreed following a consensus meeting representatives from ESMO, EURACAN, GENTURIS and ERNPaedCan.•Authorship includes multidisciplinary group experts different institutions countries worldwide. Primary sarcomas (BSs) account for <0.2% malignant neoplasms across all ages.1...