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Arizona Station. The Station demonstrated that hepatocyte growth factor (HGF) may be involved in linking mechanical perturbation of muscle to satellite cell activation. Involvement of NO in HGF release and satellite cell activation during stretch was also demonstrated, indicating that stretch triggers an intracellular cascade of events including NO synthesis, resulting in HGF release and satell...

Background: Prostate specific antigen (PSA) is an important biomarker to monitor patients after treated with radiation therapy (RT). The aim of this study is to evaluate the relationship between the PSA data and prostate cancer recurrence using the joint modeling. Methods: This historical cohort study was performed on 422 prostate cancer patients. Inclusion criteria included: patients with loc...

OBJECTIVES Dermatophytes, belonging to genera including Trichophyton, Epidermophyton, and Microsporum, are the causative agents of superficial fungal infections, prevalences of which are estimated to be as high as 25% in the worldwide population. This study evaluated the activity of topical formulations of NVC-422 (sodium 2-[dichloroamino]-2-methylpropane-1-sulfonate), the lead compound in a ne...

During oxidative burst, neutrophils selectively generate HOCl to destroy invading microbial pathogens. Excess HOCl reacts with taurine, a semi-essential amino acid, resulting in the formation of the longer-lived biogenerated broad-spectrum antimicrobial agent, N-chlorotaurine (NCT). In the presence of an excess of HOCl or under moderately acidic conditions, NCT can be further chlorinated, or it...

Background, In this study, we sought to determine the prevalence, types, and maternal-fetal transmission of HPV in pregnant women in Nanjing, Jiangsu Province. Results, The overall cervical HPV-DNA positivity rate among pregnant women was 13.44% (422/3139). The most frequently detected HPV types in mothers were HPV-16 (29.62%, 125/422), HPV-18 (14.69%, 62/422), and HPV-58 (14.22%, 60/422). The ...

PURPOSE Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthalmic viral pathogens. METHODS The virucidal activity of NVC-422 against seve...