introduction: different environmental factors such as drugs, ionizing radiation, etc can induce apoptosis.in the present study the effects of dose- rate and post-irradiation incubation time on gamma radiation inducedapoptosis in human breast carcinoma cell line (t-47d) (invasive ductal carcinoma) was investigated. material and methods: the t-47d cells were cultured in t25 flasks and during log ...

study of the different aspects of protection against the exposure of ionizing radiation has always been an active area of research. high cost and toxicity of radioprotective drugs have limited their use. so, search for new drugs with a high degree of protection and lower cost and side effects seem a necessity. in this study radioprotective effect of aqueous as well as alcoholic extracts of the ...

Allograft safety is contingent on effective sterilization methods such as gamma irradiation. However, recent clinical studies have associated gamma irradiation with decreased graft strength and increased allograft failure rates, despite data that shows no deleterious effects to soft tissue biomechanics at gamma doses between 1.46 and 2.18 mRad. The objective of this study was to compare the bio...

PURPOSE To investigate whether interleukin-1beta-converting enzyme (ICE), a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3, is involved in gamma-irradiation-induced apoptosis (programmed cell death) of human retinoblastoma cells. METHODS The induction of apoptotic cell death in human retinoblastoma cell lines WERI-Rb-1 and Y79 by gamma-irradiation was determined with ...

Gamma irradiation is able to affect various structural and biological properties of biomaterials In this study, a composite of Hap/PLGA-PEG and their ingredients were submitted to gamma irradiation doses of 25 and 50 KGy. Various properties such as molecular weight (GPC), thermal behavior (DSC), wettability (contact angle), cell viability (MTT assay), and alkaline phosphatase activity were stud...

Irradiation for phytosanitary purposes. Is it a myth, or a viable alternative to chemical treatments? Plant mutation breeding at Southern Cross University-irradiation and how it relates to other technologies 1345 Michael Colella, ANSTO The contribution of gamma irradiation to forensic counter-terrorism research activities 1400 Yoichi Furuya, ANU Gamma-ray inactivated influenza A virus vaccine f...

Gamma-irradiation leads to apoptosis and cell cycle arrest in eukaryotic cells. Olomoucine is a novel purine analog acting as a cyclin-dependent kinase inhibitor. The effects of olomoucine in gamma-irradiation mediated cell growth inhibition and apoptosis were studied in the Raji cell line (Burkitt's lymphoma). Gamma-irradiation caused a G2 arrest, increasing the G2/M fragment of the cells. Apo...

Gamma irradiation sterilization (gamma-irradiation) fragments and denatures collagen, drastically decreasing critical physical properties. Our goal was to maintain strength and stability of gamma-irradiated collagen by adding glucose, which in theory can initiate crosslink formation in collagen during exposure to gamma-irradiation. Collagen films prepared with and without glucose were gamma-irr...

Gamma (gamma)-irradiation is finding increasing use in the sterilization of pharmaceutical products. However, irradiation also might affect the performance of drug delivery systems. In this study, the influence of gamma-irradiation on the characteristics of chitosan microparticles was investigated. The diclofenac sodium was incorporated into chitosan microparticles by spray-drying method. The c...

introduction: white spot syndrome virus (wssv) is one of the most deadly infectious pathogens of the shrimp culture industry. neither effective vaccines nor efficient treatments are currently available for this disease. vibrio species are well known dominant bacterial pathogens in the shrimp ponds. as facultative pathogenic bacteria, it is possible that vibrio spp. along with wssv to co-infect ...