AIM OF THE STUDY We determined the expression of beclin-1 in gallbladder carcinoma, analyzed the association of beclin-1 expression with clinicopathologic parameters and prognosis, and investigated the relationship between microvessel density and beclin-1 expression. MATERIAL AND METHODS Tissue microarray blocks containing 118 primary gallbladder tumor sites were used. Clinical parameters and...

Gallbladder carcinoma is an exceedingly rare and fatal cancer. With stage 1 disease having a 5-year survival of only 50%, a diagnosis of gallbladder cancer carries a grim prognosis. Fortunately, especially in the developed world, it is exceedingly rare. Annual rates are reported as low as 1 - 2.5 per 100,000 people in the United States. Over the past 14 years, Newark Beth Israel in New Jersey h...

BACKGROUND Although 5-Fluorouracil (5-FU) is widely used in chemotherapeutic treatment for gallbladder cancer, there is little evidence of its effectiveness. Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are the major determinants of individual sensitivity to 5-FU, and the impact of TS and DPD expression on prognosis and 5-FU efficacy has been studied in gastrointestinal c...

BACKGROUND Clinical significance of survivin (antiapoptosis protein) in gallbladder cancer is not yet established. AIMS This study was performed to assess the expression pattern of survivin in benign and malignant gallbladder lesions using immunohistochemistry (IHC), and to assess its clinicopathological significance. SETTINGS AND DESIGN Prospective study from July 2012 to July 2014 was per...

Primary pure squamous cell carcinoma (SCC) of the gallbladder is an exceptionally rare type of tumor that comprises only 1% of all gallbladder cancer. SCC of the gallbladder portends a worse prognosis than the more common adenocarcinoma variant because of its aggressive invasion to local structures and because it is often diagnosed at an advanced stage. Owing to its rarity, diagnosis and manage...

Gallbladder (GB) cancer is the most common malignant lesion of the biliary tract. The decision for a cholecystectomy in asymptomatic cholelithiasis as a measure of the secondary prevention of gallbladder cancer is based on the data of incidence and selected predictive factors for a specific population. A consecutive series of 3351 cholecystectomies in five year period was reviewed. That data wa...

Primary neuroendocrine carcinoma of the gallbladder is extremely rare because normal gallbladder mucosa does not contain neuroendocrine cells. Neuroendocrine cells can be detected at sites of intestinal metaplasia induced by chronic inflammation, which may be the initial step in the development of neuroendocrine tumor of the gallbladder. Anomalous union of the pancreaticobiliary duct (AUPBD) is...

OBJECTIVE To evaluate the risk factors and assess the short-term prognosis and independent prognostic factors of cases of gallbladder cancer. METHODS A retrospective analysis of the data of 52 patients of gallbladder cancer was done. Clinical presentation, laboratory investigations, treatment given, operative findings and histopathological findings were reviewed. RESULTS Forty-four patients...

Gallbladder cancer (GBC) is a rare but highly malignant neoplasm. Most cases are discovered incidentally in patients undergoing evaluation for gallstone disease. It believed that an unfavorable prognosis associated with RZD late stage at diagnosis, which due to both the anatomical position of gallbladder and vagueness non-specificity symptoms, increases relevance studying highlighting this topi...

Gallbladder cancer (GBC) is the most common malignancy in the biliary tract. Without effective treatment, its prognosis is notoriously poor. Tea polyphenols (TPs) have many pharmacological and health benefits, including antioxidant, anti-inflammatory, anti-tumor, anti-thrombotic, antibacterial, and vasodilatory properties. However, the anti-cancer effect of TPs in human gallbladder cancer has n...