Eleven years have passed since Rous and McMaster (15) published their paper on the concentrating activity of the gall bladder. This contribution and subsequent ones by them and their associates renewed the interest of investigators in this organ. Two schools have developed, each with a different fundamental concept of gall bladder function. The one, following what would appear to be the more lo...

The effects of cigarette smoking and parity on the development of symptomatic gall bladder disease remain controversial. These relations have been examined in a cohort of 46000 women followed for up to 19 years during the Royal College of General Practitioners' (RCGP) oral contraception study. During follow up, 1087 women were recorded as experiencing their first ever episode ofsymptomatic chol...

The actual activity of ionised calcium (Ca2+) in gall bladder bile determined with an ion-selective electrode was significantly higher in patients with gall stone disease (n = 15) than in patients without gall stones (n = 10) (0.43 mmol/kg v 0.31 mmol/kg; p < 0.05). No change in the Ca2+ activity in any of the gall bladder bile samples was observed during equilibration with CO2. During titratio...

It has been demonstrated that lysolecithin (lysophosphatidyl choline, LPC) produces experimental cholecystitis in cats mediated by arachidonic acid metabolites. LPC is a cytolytic agent that has been postulated as a contributing factor in the development of cholecystitis in humans. The purpose of this research was to evaluate the effect of LPC on human gall-bladder mucosal cell phospholipase A(...

INTRODUCTION Perforation of the gall bladder represents a rare, but life-threatening complication of cholecystitis. Clinical presentation may vary between severe peritonism in acute perforation and absence of symptoms in subacute or chronic progression of perforation. Abdominal imaging like ultrasound or CT-scan are important tools for immediate diagnose of gall bladder perforation. CASE PRES...

Malakoplakia, a rare inflammatory condition usually occurring in the urinary tract, may occasionally be seen in other viscera, including the gall bladder. We describe one of the few cases of malakoplakia in the gall bladder, wherein, due to diagnostic confusion with carcinoma as well as operative difficulty, open cholecystectomy was necessitated. Malakoplakia of the gall bladder may be seen rar...

Nitric oxide (NO) serves as a neurotransmitter in the nonadrenergic and non-cholinergic (NANC) inhibitory pathway of the gastrointestinal tract. Several findings have demonstrated the presence of NO-synthase containing nerve fibers and neurons in the wall of the gall bladder and biliary pathways of several mammals including man and NO serves as a modulator in the control of the contractions of ...

Gall bladder perforation is a potentially life-threatening condition. Spontaneous perforation is infrequent and rarely seen in the absence of gallstones but gall bladder perforation is an occasional complication of typhoid fever. If such perforations are not treated in time, mortality rates are very high. We report a case of gall bladder perforation complicating typhoid fever following enteric ...

Background-Although polypoid lesions ofthe gall bladder are frequently observed in asymptomatic subjects, the natural history of these lesions has never been studied using ultrasonography. Aim-The natural history of polypoid lesions ofthe gall bladder was investigated using ultrasonography. Subjects-Among 4343 patients who presented to the outpatient clinic of Tsuchiura Kyodo General Hospital i...

Diseases of the gall bladder in childhood are of great interest. Recently, Forshall and Rickham (1954) and previously Potter (1938) drew attention to cholecystitis associated with gall stones. The majority of such cases do not present as acute emergencies. Fevre (1933) states that diseases of the biliary tract presenting as surgical emergencies are usually a perforation or volvulus of the gall ...