It is the purpose of this paper to present the results of aninvestigation of galactose metabolism by determining the galactose content of the blood and urine following the administration of galactose by mouth to human subjects, and by determining the galactose concentration of the blood following the subcutaneous, intravenous, or intraperitoneal administration of galactose to animals. Investiga...

The present study , was an attempt to develop galactosylated albumin nanoparticles of Simvastatin for treatment of hypercholesterolemia. By developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. The advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...

The present study , was an attempt to develop galactosylated albumin nanoparticles of Simvastatin for treatment of hypercholesterolemia. By developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. The advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...

Oral galactose tolerance tests were performed on 56 patients with liver disease, 31 with diabetes mellitus and 17 normal subjects. Intravenous galactose tolerance tests were done on 25 liver disease, 6 diabetes mellitus and 6 normal subjects. Each liver disease was histologically comfirmed by needle biopsy under laparoscopy. Serum galactose and glucose were measured gaschromatographically. Oral...

The two optical forms of aldohexose galactose differing at the C-1 position, alpha-D-galactose and beta-D-galactose, are widespread in nature. The two anomers also occur in di- and polysaccharides, as well as in glycoconjugates. The anomeric form of D-galactose, when present in complex carbohydrates, e.g., cell wall, glycoproteins, and glycolipids, is specific. Their interconversion occurs as m...

Galactose-nonfermenting (Gal) Streptococcus thermophilus TS2 releases galactose into the extracellular medium when grown in medium containing excess lactose. Starved and de-energized Gal cells, however, could be loaded with galactose to levels approximately equal to the extracellular concentration (0 to 50 mM). When loaded cells were separated from the medium and resuspended in fresh broth cont...

For many years clinical interest in D-galactose centered about the usefulness of galactose tolerance tests in the diagnosis of impaired liver function. Several investigators, employing an intravenous galactose tolerance test, have reported their results (1-3). The monograph by Stenstam (4) is perhaps the most extensive analysis of both the oral and intravenous tolerance test yet reported. In al...

In galactosemia, prevention of mental retardation depends on early recognition of the disorder and institution of dietary restriction of galactose. We describe an automated fluorometric micromethod for galactose in whole blood spotted on filter paper. Galactose is oxidized by galactose oxidase to D-galacto-hexadialdose and H2O2 and measured as the highly fluorescent condensation product of homo...

Cataracts may arise in association with various major and minor disorders restricting galactose metabolism, and the risk is broadly associated with the degree of galactose intolerance. A family is described in which a girl presented at the age of 7 3/4 years with cataracts, galactosuria, and partial deficiencies of the enzymes galactokinase and galactose-1-phosphate uridyl transferase. Galactos...

Classical galactosaemia is an inherited inborn error of the major galactose assimilation pathway, caused by galactose-1-phosphate uridyltransferase (GALT) deficiency. Many GALT mutations have been described, with different clinical consequences. In severe forms, newborns present with a life-threatening, acute toxic syndrome that rapidly regresses under a galactose-restricted diet. However, long...