نتایج جستجو برای: gadolinium
تعداد نتایج: 11285 فیلتر نتایج به سال:
SEE PAGE 1019 C ardiac magnetic resonance (CMR) late gadolinium enhancement (LGE) (1) is the current clinical gold standard modality for evaluation of focal fibrosis and scar in patients with an ischemic or a nonischemic cardiomyopathy. LGE requires administration of an exogenous gadoliniumbased contrast agent, which accumulates in the scar region. LGE imaging is commonly performed using an inv...
The purpose of this study was to develop an in vivo imaging tool to monitor vascular gene transfer. We produced gadolinium/blue-dye and gadolinium/gene-vector media by mixing Magnevist with a trypan-blue or a lentiviral vector carrying a green fluorescent protein (GFP) gene. The gadolinium was used as an imaging marker for MRI to visualize vessel wall enhancement, while the blue-dye/GFP was use...
Several MRI contrast agents (CAs) are used in medical diagnosis that gadolinium (Gd3+) is the most widely used as contrast agents. Unfortunately, its toxicity is due to its inefficiency. In this review, we discuss about the ability of SPIONs in MRI and application in Multiple Sclerosis diagnosis. Superparamagnetic iron oxide nanoparticles (SPIONs) such as magnetite nanoparticles are used as goo...
In 2006, a connection was made between Gadolinium-based Contrast Agents (GBCAs) administered for contrast-enhanced MRIs and Nephrogenic Systemic Fibrosis (NSF). NSF is a potentially fatal disease that has been diagnosed almost exclusively in patients with end-stage renal disease (ESRD). Prolonged excretion times and the instability of the GBCA results in the toxic gadolinium ion separating from...
OBJECTIVE Gadolinium neutron capture therapy (GdNCT) is a potential treatment for malignant tumors based on two steps: (1) injection of a tumor-specific (157)Gd compound; (2) tumor irradiation with thermal neutrons. The GdNC reaction can induce cell death provided that Gd is proximate to DNA. Here, we studied the nuclear uptake of Gd by glioblastoma (GBM) tumor cells after treatment with two Gd...
This present study has been described the synthesis, characterization and antibacterial activity of gadolinium doped cerium oxide nanoparticles. The nanoparticles were prepared by hydrothermal method with various concentrations of gadolinium ranges from 2 mol% to 8 mol%. The X-ray diffraction (XRD) pattern revealed the face-centered cubic structure with crystalline size of 58.3 nm to 57.4 nm wi...
Introduction: The intravenous (IV) administration of Gadolinium is routinely used in both human and animal imaging for the diagnosis of lesions that compromise the blood-brain barrier (BBB). Although it is relatively trivial in humans and larger animals, gaining IV access in the mouse turns out to be challenging (1). Mouse IV injections are most commonly administered via one of the two tail vei...
Mechanosensitive cation channels (MSC) are ubiquitous in eukaryotic cell types. However, the physiological functions of MSC in several tissues remain in question. In this study we have investigated the role of MSC in skeletal myogenesis. Treatment of C2C12 myoblasts with gadolinium ions (MSC blocker) inhibited myotube formation and the myogenic index in differentiation medium (DM). The enzymati...
BACKGROUND Cardiac involvement is common in amyloidosis and associated with a variably adverse outcome. We have previously shown that cardiovascular magnetic resonance (CMR) can assess deposition of amyloid protein in the myocardial interstitium. In this study we assessed the prognostic value of late gadolinium enhancement (LGE) and gadolinium kinetics in cardiac amyloidosis in a prospective lo...
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