Previous studies demonstrated that stimulation of type B gamma-aminobutyric acid (GABAB) receptors but not type A (GABAA) receptors in the nucleus tractus solitarius of spontaneously hypertensive rats elicited a larger increase in arterial pressure compared with control rats of the Wistar-Kyoto strain. The present studies extended that observation by examining the cardiovascular response to inj...

g -aminobutiric acid (gaba), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (gabaa and gabab). gabab receptors are activated by the antispastic and muscle relaxant agent, baclofen, which is a lipophilic derivative of gaba. since 1962 several strategies have been reported for the synthesis of baclofen.in this study an approach has been made to...

Neurogliaform cells in the rat elicit combined GABAA and GABAB receptor-mediated postsynaptic responses on cortical pyramidal cells and establish electrical synapses with various interneuron types. However, the involvement of GABAB receptors in postsynaptic effects of neurogliaform cells on other GABAergic interneurons is not clear. We measured the postsynaptic effects of neurogliaform cells in...

Mechanisms of presynaptic inhibition were examined in giant presynaptic terminals of retinal bipolar neurons, which receive GABAergic feedback synapses from amacrine cells. Two distinct inhibitory actions of GABA are present in the terminals: a GABAA-like Cl conductance and a GABAB-like inhibition of voltage-dependent Ca current. Both of the receptors underlying these actions have unusual pharm...

The role of GABAB receptors in various behavioral processes has been largely defined using the prototypical GABAB receptor agonist baclofen. However, baclofen induces sedation, hypothermia and muscle relaxation, which may interfere with its use in behavioral paradigms. Although there is much evidence for a role of the inhibitory neurotransmitter GABA in the pathophysiology of anxiety, the role ...

GABAB receptors are G-protein-coupled receptors that mediate inhibitory synaptic actions through a series of downstream target proteins. It is increasingly appreciated that the GABAB receptor forms part of larger signaling complexes, which enable the receptor to mediate multiple different effects within neurons. Here we report that GABAB receptors can physically associate with the potassium-chl...

g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the synthesis of baclofen.In this study an approach has been made to...

26 Besides its quintessential role in reproduction, 17β-estradiol (E2) is a potent anorexigenic 27 hormone. E2 and the selective Gq-coupled membrane estrogen receptor (Gq-mER) ligand, 28 STX, rapidly increase membrane excitability in proopiomelanocortin (POMC) neurons by 29 desensitizing the coupling of GABAB receptors to G protein-coupled inwardly rectifying K 30 channels (GIRKs), which upon a...

background: the ventral tegmental area (vta) is well known for its role in cardiovascular control. it is demonstrated that about 20-30% of the vta neurons are gabaergic though their role in cardiovascular control is not yet understood. this study is carried out to find the effects of gaba a and gaba b receptors on cardiovascular response of the vta. methods: experiments were performed on uretha...