Effective reservoir operation under the effects of climate change is immensely challenging. The accuracy inflow forecasting one essential factors supporting operations. This study aimed to investigate coupling models feature selection (FS) and machine learning (ML) algorithms predict monthly inflow. was carried out using data from Huai Nam Sai in southern Thailand. Eighteen years recorded (i.e....

A comparative workflow, including linear and non-linear QSAR models, was carried out to evaluate the predictive accuracy of models and predict the inhibition activity of a series of aryl-substituted isobenzofuran-1(3H)-ones. The data set consisted of 34 compounds was classified into the training and test sets, randomly. Molecular descriptors were selected using the genetic algorithm (GA) as a f...

1-[4-(2-Alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. These compounds demonstrate low micromolar to submicromolar IC50 values against human Molt 4/C8 and CEM T-lymphocytes and murine leukemia L1210 cells. In this study, a comparative QSAR investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...

The COVID-19 has been creating a global crisis, causing countless deaths and unbearable panic. Despite the progress made in development of vaccine, there is an urge need for discovery antivirals that may better work at different stages SARS-CoV-2 reproduction. main protease (Mpro) crucial therapeutic target due to its critical function virus replication. ?-ketoamide derivatives represent import...

Accurate ozone concentration simulation can provide a health reference for people’s daily lives. Simulating concentrations is complex task because near-surface production determined by combination of volatile organic compounds (VOCs) and NOx emissions, atmospheric photochemical reactions, meteorological factors. In this study, we applied genetic algorithm-optimized back propagation (GA-BP) neur...

BACKGROUND To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma. METHODS We retrospectively evaluated the clinical features of 121 patients with gastric adenocarcinoma enrolled in our hospital between 2000 and 2007. The receiver operating characteristic (ROC) curve was used to determine the c...

COVID-19 prediction models are highly welcome and necessary for authorities to make informed decisions. Traditional models, which were used in the past, unable reliably estimate death rates due procedural flaws. The genetic algorithm association with an artificial neural network (GA-ANN) is one of suitable blended AI strategies that can foretell more correctly by resolving this difficult phenom...

BACKGROUND The middle latency response (MLR) can be a powerful tool for assessing integrity of cortical and subcortical auditory structures. Most research on the MLR, however, is constrained to relatively slow repetition rates by the time window necessary for response acquisition. Maximum length sequence (MLS) paradigms enable the recording of the MLR at high repetition rates, which could reduc...