Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligandfor the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathwayhas been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluidhomeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cellp...

The hypothalamic-pituitary-adrenal (HPA)-axis regulates the response to stressful events and is expected to be involved in the pathogenesis of depression. The glucocorticoid receptor (GR) regulates the activity of the HPA-axis. Both GR gene polymorphisms and childhood adversity are known to be associated with increased risk for depression. In the Longitudinal Aging Study Amsterdam, a large popu...

Considering the evolution equations of parabolic type on a non-compact Einstein manifold $(\mathcal M,g)$ with negative Ricci curvature tensor, we establish results existence, uniqueness time-periodic (on time half-axis) and almost periodic

The effect of confectionery liquorice on electrolyte status and the renin-angiotensin-aldosterone (RAA) axis was studied in 14 healthy volunteers. They ate liquorice in daily doses of 100 g or 200 g (equivalent to 0-7-1-4 g glycyrrhizinic acid) for one to four weeks. Plasma potassium concentrations fell by over 0-3 mmol/l in 11 people, including four who had to be withdrawn from the study becau...

Fused deposition modeling (FDM) 3D printers commonly need support material to print overhangs. A previously developed 4-axis printing process based on an orthogonal kinematic, additional rotational axis around the z-axis and a 45° tilted nozzle can overhangs up 100° without material. With this approach, layers are in conical shape no longer parallel plane; therefore, new slicer strategy is nece...

The microwave spectrum of trans-2,3-dimethyloxirane ( C H 3 C H O C H C H 3 ) in the excited torsional states u17 = 1 and vi3 — 1 has been measured in the range from 8 to 26 G H z and assigned. An analysis of internal rotat ion splittings of the observed rotational transitions was performed using the internal axis method (or "combined axis method") with a newly developed program accounting for ...

The electron paramagnetic resonance parameters zero-field splitting D and g factors g‖ and g⊥ of three tetragonal centers in CsCl: Cr3+ crystal at room temperature have been investigated by a two-spin-orbit (S. O.)-coupling parameter model. In this model, the contributions arising from the S. O. coupling of the central d3 ion and the ligands are included. For center III, the very small D of the...

An axis parallel d-dimensional box is the Cartesian product R1×R2×· · ·×Rd where each Ri is a closed interval on the real line. The boxicity of a graph G, denoted as box(G), is the minimum integer d such that G can be represented as the intersection graph of a collection of d-dimensional boxes. An axis parallel unit cube in d-dimensional space or a d-cube is defined as the Cartesian product R1 ...

objective(s) the mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (hpa) axis remain elusive. the endocannabinoid system (ecbs) which exhibits antidepressant potential, appears to regulate the hpa axis activity. therefore, we aimed to investigate the role of the ecbs in the action of doxepin including its effect on the hpa axis. materials and methods male wistar ...

Let g(z, x) denote the diagonal Green's matrix of a self-adjoint m × m matrix-valued Schrödinger operator H = − d 2 dx 2 Im + Q(x) in L 2 (R) m , m ∈ N. One of the principal results proven in this paper states that for a fixed x 0 ∈ R and all z ∈ C + , g(z, x 0) and g ′ (z, x 0) uniquely determine the matrix-valued m × m potential Q(x) for a.e. x ∈ R. We also prove the following local version o...