The induction of unscheduled DMA synthesis in primary cultures of urothelial cells from rats, mice, and dogs by nitrofurans and arylamines and their derivatives was examined. Electron microscopy of the culture from rat cells showed the characteristics of epithelial cells. The cultured cells were ex posed to the test chemicals in a serum-free medium containing 10 HIMhydroxyurea and [3H]thymidine...

Arylfuran’s are an important class of compounds in practical terms. The availability and broad functionality arylfuran derivatives open wide opportunities for obtaining a significant variety potential biologically active substances. It is known that many have been found based on derivatives, moreover number drugs discovered. Functionalized furans, particular aldehydes the series, frequently use...

A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR and Mass spectra. All newly synthesized compounds were evaluated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv using the microplate alamar blu...

A sodium salt of 2-(fur-2-yl)-6-nitro-1,2,4-triazolo[1,5-a]pyrimidin-7-one as a close structural analogue ZM-241385 was obtained. This heterocycle can serve an effector for A2a adenosine receptors and possesses antiseptic activity. The structures compounds were confirmed based on the data 1H, 13C NMR spectroscopy, IR elemental analysis. structure 2-furyl-6-nitro-1,2,4-triazolo[1,5-a]pyrimidin-7...

In the title mol-ecule, C(16)H(16)N(4)O(2)S, the plane of the 1,2,4-triazole ring forms dihedral angles of 77.9 (2) and 30.0 (2)° with the planes of the furyl and phenyl rings, respectively. Weak inter-molecular N-H⋯S and C-H⋯O hydrogen bonds consolidate the crystal packing.