As a part of our search for hepatoprotective compounds from Lycium chinense fruits, three new pyrrole derivatives (1-3) were isolated. These compounds and a related synthetic methylated compound (4) were evaluated for their biological activity and structure-activity relationship, and compounds 1 and 2 showed hepatoprotective effects comparable to silybin at the concentration of 0.1 microM (64.4...

INTRODUCTION The acetogenin, annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina triloba (pawpaw) is native to the Eastern United States and products are available online. This study determined whether annonacin is in the pawpaw...

The main objective of this study is to evaluate the anti-oxidant properties in methanolic extract of Leaves and fruit of cucumies melo () The methanol leaf extract noticed significant scavenging activity on DPPH, superoxide, nitric oxide , hydrogen peroxide and hydroxyl radical. The total phenolic compounds were found to be high with leaves rather than the flesh of fruit.

the objective of the study was to evaluate the cytotoxic effects of aqueous extract of cucumis melo fruit on human prostate cancer cell line (pc-3) using mtt and neutral red assays. the crude aqueous extract of c. melo was prepared by cold maceration method, filtered, concentrated and tested on pc-3 cell line. dose-dependent cytotoxic activities were exhibited on human prostate carcinoma pc-3 c...

The objective of the study is to evaluate the hypoglycemic activity of Barringtonia acutangula (BA) fruit extracts i.e. aqueous, methanol and chloroform in streptozotocin (STZ) 50mg /kg induced hyperglycemic Wistar rats. In addition, the effect off all the three extracts of BA fruit on oral glucose tolerance in glucose loaded normal rats was also determined. Aqueous extract (400 mg/kg) treatmen...

This study was aimed to investigate the effects of cream containing Ficus carica L. fruit (Fig) extract on various skin parameters such as skin melanin, erythema, moisture content, trans-epidermal water loss and sebum. For this purpose, formulation with 4% concentrated extract of F. carica fruit and base without extract were developed. Base served as a control. Both base and formulation were ap...

Purpose: To evaluate the antiurolithiatic activity of Pinus eldarica fruit on induced calcium oxalate nephrolithiasis in rats. Materials and Methods: Calcium oxalate nephrolithiasis in rats was induced by administering ethylene glycol 1% for 30 days via drinking water. The prophylactic and therapeutic groups received P. eldarica fruit extract (500 and 1000 mg/kg/day) as well for 30 days and fro...

Diabetes mellitus is a multisystemic metabolic disorder as old as mankind that has reached epidemic proportions worldwide. Though drugs are plenty for the treatment of diabetes, none is found to be ideal due to undesirable side effects and diminution after prolonged use. Hence, search for novel drugs, especially from plant origin continues. Pithecellobium dulce Benth, (Leguminosae) commonly kno...

Diabetes mellitus is regarded as a serious chronic disease that carries a high risk for considerable complications. In folk medicine, the edible Grewia asiatica fruit is used in a number of pathological conditions. This study aimed to investigate the possible curative effect of G. asiatica fruit ethanolic extract against streptozotocin- (STZ-) induced hyperglycemia in rats. Furthermore, mechani...