N. Neittaanmäki, M. Salmivuori, I. Pölönen, L. Jeskanen, A. Ranki, O. Saksela, E. Snellman, M. Grönroos (1) Department of Clinical Pathology, Sahlgrenska University hospital, Göteborg, Sweden (2) Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland (3) Department of Mathematical Information Technology, University of Jyväskylä, Finland (4) Departmen...

Lentigo maligna is a melanocytic neoplasm occurring on sun-exposed skin, usually on the head and neck, of middle-aged and elderly patients. It is thought to represent the in situ phase of lentigo maligna melanoma. The ill-defined nature and potentially large size of lesions can pose significant diagnostic and treatment challenges. The goal of therapy is to cure the lesions in order to prevent d...

Facial lentigo maligna melanoma can be a diagnostic challenge in daily clinical practice as it has similar clinical and morphological features to other lesions such as solar lentigines and pigmented actinic keratoses. Confocal microscopy is a noninvasive technique that provides real-time images of the epidermis and superficial dermis with cellular-level resolution. We describe 3 cases of suspec...

A 56-year-old man presented with a pigmented lesion on the right preauricular cheek. A biopsy specimen demonstrated lentigo maligna. The lesion was excised in a standard fashion with 0.5-cm margins. Histologic evaluation of the excised specimen showed persistence of the tumor at the surgical margin. A second attempt at excision failed to fully excise the tumor. The patient was referred to our i...

A Rayleigh number based criterion is developed for predicting the formation of freckles in Ni-base superalloy castings. This criterion relies on finding the maximum local Rayleigh number in the mush, where the ratio of the driving buoyancy force to the retarding frictional force is the largest. A critical Rayleigh number for freckle formation of approximately 0.25 is found from available experi...

BACKGROUND Freckles are due to an increase in the amount of dark pigments called melanin. These spots are more likely developed on the sun-exposed skin areas like the cheeks, nose, and forehead. Nevus is usually a benign melanocytic tumor and can be congenital or acquired. Due to the high influence of skin lesions on the person's appearance and quality of life, the aim of this study was to eval...

A criterion for predicting the formation of freckles for Pb-Sn and Ni-base superalloys is evaluated using available experimental data. The criterion is based on a maximum value of the Rayleigh number, which indicates that the magnitude of buoyancy forces is largest with respect to the retarding frictional forces. The definition of the Rayleigh number involves a characteristic length scale. The ...

ABSTRACT: Tomato plants are a crop of great economic importance worldwide. Mexico is considered the world’s leading exporter this vegetable, with 24% market share. However, can be affected by diseases such as bacterial freckle and cancer that introduced to plantations through infected seeds. Pesticides used in agriculture for disease control source environmental pollution. Alternatives use pest...

Lentigo maligna is a lentiginous proliferation of atypical melanocytes confined to the epidermis, typically on chronically sun-damaged skin. Following biopsy and exclusion of invasive disease, therapy may involve Mohs surgery, topical treatment or radiotherapy. However, lentigo maligna often involves adnexal structures, creating histological difficulty in distinguishing these foci from invasive...