Male inbred F344 weanbing rats were fed semipunified diets containing 20 or 5% beef fat. At 7 weeks of age, all animals except controls were given 1,2-dimethylhydrazine [DMH (150 mg/kg body weight s.c.; one dose)], methyl azoxymethanol acetate [MAM acetate (35 mg/kg body weight i.p.; one dose)], or methylnitrosourea (2.5 mg/rat/ week intrarectally; two doses), and autopsied 35 weeks later. No m...

The inilnû oncogene encodes a 90-kDa nuclear phosphoprotein that binds and inhibits the function of the p53 tumor suppressor protein. It was recently reported that the expression of alternatively spliced variants of uiclm2 correlated with malignancy in ovarian tumors and bladder carci nomas. We analyzed the presence of alternatively spliced mdm2 variants and studied their correlation to p53 st...

Ethanol extract (FRE) and water extract (FRW) of Ficus racemosa (family: Moraceae) were subjected to free radical scavenging both by steady state and time resolved methods such as nanosecond pulse radiolysis and stopped-flow spectrophotometric analyses. FRE exhibited significantly higher steady state antioxidant activity than FRW. FRE exhibited concentration dependent DPPH, ABTS(*-), hydroxyl r...

Altered regulation of 5-HT1A receptors is implicated in mood disorders such as anxiety and major depression. To provide insight into its transcriptional regulation, we previously identified a novel DNA element [14 bp 5'-repressor element (FRE)] of the 5-HT1A receptor gene that mediates repression in neuronal and non-neuronal cells (Ou et al., 2000). We have now cloned a novel DNA binding protei...

In the background of weak, if any, constitutive SOS function, RecA from Pseudomonas aeruginosa (RecAPa) shows a higher frequency of recombination exchange (FRE) per DNA unit length as compared to RecA from Escherichia coli (RecAEc). To understand the molecular basis for this observation and to determine which regions of the RecAPa polypeptide are responsible for this unusual activity, we analyz...

Constipation is a common problem in males and females. The aim of the present study was to evaluate the laxative effects of fermented rice extract (FRe) on rats with loperamide-induced constipation. FRe (100, 200 and 300 mg/kg) was administered orally once per day for six days following 1 h loperamide treatment. The laxative effects of FRe were compared with those of sodium picosulfate (S. pico...

Subject and Purpose. The sporadic radio emissions coming from the Sun in a broad frequency range contain lot of important information concerning solar corona, parameters sources therein, parameter variations resulting active processes on about Sun. These have been reasons for recent launches space missions intended stud- ying its such as Parker Solar Probe (PSP) Orbiter. present work is aimed a...

1 Laboratoire de Géophysique Interne et de Tectonophysique, BP 53, 38041 Grenoble Cedex 9, France 2 Seismological Laboratory, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA 3 Institut de Physique du Globe, 4 place Jussieu, 75252 Paris Cedex 05, France 4 now at: Laboratoire de Modélisation et d’Imagerie en Géosciences CNRS FRE 2639, Université...

RecAX53 is a chimeric variant of the Escherichia coli RecA protein (RecAEc) that contains a part of the central domain of Pseudomonas aeruginosa RecA (RecAPa), encompassing a region that differs from RecAEc at 12 amino acid positions. Like RecAPa, this chimera exhibits hyperrecombination activity in E. coli cells, increasing the frequency of recombination exchanges per DNA unit length (FRE). Re...

The traditional Richards' equation implies that the wetting front in unsaturated soil follows Boltzmann scaling, with travel distance growing as the square root of time. This study proposes a fractal Richards' equation (FRE), replacing the integer-order time derivative of water content by a fractal derivative, using a power law ruler in time. FRE solutions exhibit anomalous non-Boltzmann scalin...