Erythrocytes containing haemoglobin C do not lyse normally in the peroxidase channel of the Technicon H6000 automated cell counter. This interferes with the normal function of the channel and results in a characteristic abnormal pattern. This correlates with a reduced osmotic fragility of the red cells.

The aim of this commentary is to address a number of issues and omissions arising from the integrative review of Bulmer-Smith et al. (2009) on emotional intelligence (EI) and nursing. An important objective is to bring to the attention of readers the growing research on trait EI (or trait emotional self-efficacy), which did not feature in Bulmer-Smith et al.’s review. As a scientific alternativ...

The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 microgram kg-1 and 250 microgram kg-1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischaemic exercise while the plasma ketamine concentration was greater than 100 ng ml-1. Ketamine was distributed ra...

Research on state fragility has seldom examined questions of persistence and transition of states. We develop a sixfold typology of states to examine how key structural features of states evolve and contribute to successful exits from fragility in some cases and persistence in others. Particularly worrisome is the lack of positive transition among the weakest states. Our findings are derived fr...

This paper, introduces a new methodology for the design and analysis of digital watermarking systems which, from an information theoretic point of view, incorporates robustness and fragility. The proposed methodology is developed by focusing on the probability of error versus watermark-to-noise ratio curve, describing the technique performance, and a scenario for coded techniques which takes in...

Abnormalities in osmotic fragility have been observed in hereditary spherocytosis, hereditary elliptocytosis, pyruvate kinase deficiency, thalassaemia and iron-deficient red cells (1). Harris et al have reported a decrease in osmotic fragility of the red cells of sickle cell anaemia patients from Africa (2). The Indian patients are genetically and clinically different from the African patients ...

I T HAS been demonstrated by Fahraeus’4 that normal red blood cells have a tendency to bcccme spheroidal in shape after standing in vitro at body ternperature. G#{228}nsslen,5 Haden6 and Castle and Daland7 have shown that spheroidal red cells are more susceptible to osmotic hemolysis than are normal corpuscles. Haden found that normal red cells when suspended in graded hypotonic salt solutions ...

Many polymers exhibit much steeper temperature dependence of their structural relaxation time (higher fragility) than liquids of small molecules, and the mechanism of this unusually high fragility in polymers remains a puzzle. To reveal additional hints for understanding the underlying mechanism, we analyzed correlation of many properties of polymers to their fragility on example of model polym...

OBJECTIVE The prevalence of subclinical contributors to low bone mineral density (BMD) and/or fragility fracture is debated. We evaluated the prevalence of subclinical contributors to low BMD and/or fragility fracture in the presence of normal 25-hydroxyvitamin D (25OHVitD) levels. DESIGN Prospective observational study. METHODS Among 1095 consecutive outpatients evaluated for low BMD and/o...

UNLABELLED In this study, we demonstrate a high prevalence of secondary factors in patients with a recent fracture independently of bone mineral density (BMD). Our results suggest that patients with a recent fracture should be screened for secondary factors for bone fragility regardless of BMD values. INTRODUCTION Secondary factors for bone fragility are common in patients with osteoporosis w...