نتایج جستجو برای: fragile histidine triad protein
تعداد نتایج: 1262078 فیلتر نتایج به سال:
presence of at least one tumor suppressor gene in this chromosomal region. However, the observation that allelic losses often involve most of 3p has hampered the isolation of the involved gene(s). Candidate loci have been identified such as the von Hippel–Lindau gene, located at 3p25, located in a region within 3p21 were reported to be sites of recurrent homozygous deletions in SCLC (Daly et al...
The WW domain containing oxidoreductase (WWOX) gene was recently identified as a candidate tumor suppressor gene at a common fragile site, FRA16D. Because the fragile histidine triad (FHIT) gene, a tumor suppressor gene encompassing the most active, common fragile site FRA3B, is frequently deleted in various cancers, we evaluated the expression of WWOX and FHIT in 74 cases of primary hematopoie...
The Fra3B locus on chromosome 3p14.2 targeting the fragile histidine triad (Fhit) gene represents one of the most common fragile sites of the human genome and is associated with early preneoplastic and malignant disorders in multiple human tumors. Fhit was classified as a tumor suppressor; however, the molecular mechanisms of its function are not well established. Here, we report that Fhit asso...
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