نتایج جستجو برای: fragile control
تعداد نتایج: 1341839 فیلتر نتایج به سال:
autism and fragile x syndrome have multiple behavioral phenotypes in common, however there has been little research into the potential role of fragile x mental retardation protein (fmrp) in autism. we sought to measure protein levels of fmrp in the lateral cerebella of subjects with autism and matched controls. we found significantly reduced levels of fmrp (p<0.0063) in subjects with autism. th...
The formation of alternative DNA secondary structures can result in DNA breakage leading to cancer and other diseases. Chromosomal fragile sites, which are regions of the genome that exhibit chromosomal breakage under conditions of mild replication stress, are predicted to form stable DNA secondary structures. DNA breakage at fragile sites is associated with regions that are deleted, amplified ...
Fragile X syndrome is the most frequent form of inherited mental retardation and is associated with a fragile site at Xq27.3. We identified human YAC clones that span fragile X site-induced translocation breakpoints coincident with the fragile X site. A gene (FMR-1) was identified within a four cosmid contig of YAC DNA that expresses a 4.8 kb message in human brain. Within a 7.4 kb EcoRI genomi...
Blade Pitch Controller (BPC) that can cope system uncertainties is one of the most interesting topics in wind energy engineering. Therefore, this paper presents a step towards the design of robust nonfragile BPC for wind energy conversion system. The proposed approach presents all boundaries of stability region that can guarantee robust stability (RS) over a wide range of operating conditions. ...
The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we show that during mouse synaptogenesis and in human FXS fibroblasts, a dual dysr...
24 Fragile X Syndrome (FXS) is a neurodevelopmental disorder characterized by severe 25 cognitive impairments, sensory hypersensitivity, and comorbidities with autism and epilepsy. 26 Fmr1 knockout (KO) mouse models of FXS exhibit alterations in excitatory and inhibitory 27 neurotransmission, but it is largely unknown how aberrant function of specific neuronal subtypes 28 contributes to these d...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید