نتایج جستجو برای: fractalkine

تعداد نتایج: 925  

Journal: :PLoS Pathogens 2009
Jennifer Vomaske Ryan M. Melnychuk Patricia P. Smith Joshua Powell Laurel Hall Victor DeFilippis Klaus Früh Martine Smit David D. Schlaepfer Jay A. Nelson Daniel N. Streblow

While most chemokine receptors fail to cross the chemokine class boundary with respect to the ligands that they bind, the human cytomegalovirus (HCMV)-encoded chemokine receptor US28 binds multiple CC-chemokines and the CX(3)C-chemokine Fractalkine. US28 binding to CC-chemokines is both necessary and sufficient to induce vascular smooth muscle cell (SMC) migration in response to HCMV infection....

Journal: :Journal of immunology 2002
Miyuki Nishimura Hisanori Umehara Takashi Nakayama Osamu Yoneda Kunio Hieshima Mayumi Kakizaki Naochika Dohmae Osamu Yoshie Toshio Imai

Fractalkine/CX3C ligand 1 and its receptor CX3CR1 are known to mediate both cell adhesion and cell migration. Here we show that CX3CR1 defines peripheral blood cytotoxic effector lymphocytes commonly armed with intracellular perforin and granzyme B, which include NK cells, gammadelta T cells, and terminally differentiated CD8(+) T cells. In addition, soluble fractalkine preferentially induced m...

Journal: :Oncology reports 2010
Feng Li Zuoren Wang Yongcun Liu Junhui Li

There is increasing evidence that hepatocellular carcinoma (HCC) is inherently associated with the inflammatory process and the up-regulation of cytokines. Our study aimed at elucidating the role of the cytokine fractalkine in the process of HCC carcinogenesis. Expression of fractalkine in hepatocellular carcinoma cell line HepG2 was knocked-down by RNAi. Conditioned media (CMs) from HepG2 was ...

Journal: :Cancer research 2004
Shannon A Shulby Nathan G Dolloff Mark E Stearns Olimpia Meucci Alessandro Fatatis

Chemokines and their receptors might be involved in the selection of specific organs by metastatic cancer cells. For instance, the CXCR4-SDF-1alpha pair regulates adhesion and migration of breast as well as prostate cancer cells to metastatic sites. In this study, we present the first evidence for the expression of CX3CR1--the specific receptor for the chemokine fractalkine--by human prostate c...

2005
Toshio IMAI Miyuki NISHIMURA Toshihiro NANKI Hisanori UMEHARA

The migration of leukocytes into in‰amed peripheral tissues and lymphoid organs involves a cascade of molecular events ˆnely regulated by cell adhesion molecules and chemokines. Fractalkine/CX3CL1 is a membrane-bound chemokine that functions not only as a chemoattractant but also as an adhesion molecule, and is expressed on endothelial cells activated by proin‰ammatory cytokines. The fractalkin...

2017
Salwa M Abo El-Khair Mohammad A Gaballah Mamdouh M Abdel-Gawad Sherif Refaat M Ismail Ayman Z Elsamanoudy

Background Fractalkine is produced in seminal plasma in small amounts and correlates with sperm motility. Purpose To investigate the possible effect of low-level leucospermia on spermatozoa oxidative stress and sDNA fragmentation in patients with subclinical varicocele and apparently normal seminogram, and also to study the role of spermatozoal fractalkine and its receptor (CX3CR1) gene expre...

Journal: :Chemical communications 2012
Brett Waybrant Timothy R Pearce Ping Wang Srinand Sreevatsan Efrosini Kokkoli

Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.

2011
Kang Yao Hao Lu Rongchong Huang Shuning Zhang Xiaowu Hong Hongyu Shi Aijun Sun Juying Qian Yunzeng Zou Junbo Ge

BACKGROUND It has been shown that dendritic cells (DCs) and fractalkine play a role in accelerating progression of the inflamed atherosclerotic lesions and plaque rupture. We evaluated the numbers and functional changes of DCs and its subsets in human type 2 diabetes with or without unstable angina pectoris (UAP). METHODS The study population consisted of 39 diabetic patients (DM:18 without C...

Journal: :basic and clinical neuroscience 0
sasan gazerani physiology department, faculty of medicine, shahid beheshti university of medical sciences, tehran, iran jalal zaringhalam department of physiology, neurophysiology research center, shahid beheshti university of medical sciences, tehran, iran. homa manaheji physiology department, faculty of medicine, shahid beheshti university of medical sciences sahar golabi physiology department, faculty of medicine, shahid beheshti university of medical sciences

introduction: stimulation of peptidergic fibers activates microglia in the dorsal horn. microglia activation causes fractalkine (fkn) release, a neuron-glia signal, which enhances pain. the transient vanilloid receptor 1 (trpv1) mediates the release of neuropeptides, which can subsequently activate glia. trpv1 and trpv2 are generally expressed on c and aδ fibers, respectively. expression of bot...

2011
Brian Jones Alisa E. Koch Salahuddin Ahmed

Understanding rheumatic diseases from the perspective of chemokine biology has shaped and will continue to shape our approach for targeted drug design. Among different kinds of chemokines, fractalkine/CX3CL1 has been found to play an important role in inflammation, portraying unique functional, and structural characteristics. This review summarizes the emerging role of fractalkine/CX3CL1 from a...

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