Non-small cell lung cancer (NSCLC) poses a serious threat to people’s health. Its morbidity and mortality are among the highest all malignant tumors, there is an urgent need for more effective new treatment methods. In recent years, NSCLC immunotherapy has made great progress, first PD-1 inhibitor nivolumab (Nivolumab, O drug) was approved by US Food Drug Administration (FDA) in March 2015, app...

Allergen-specific IgG antibodies play a significant role in allergen-specific tolerance, either naturally induced or generated by specific immunotherapy. Nevertheless, the underlying mechanisms are still debated, and allergen-specific IgG determinations are not recommended as a diagnostic tool in IgE-mediated allergy. This review summarizes the latest findings on the immunological and diagnosti...

It is reported that 6% of children and 3% of adults have food allergies, with studies suggesting increased prevalence worldwide over the last few decades. Despite this, our diagnostic capabilities and techniques for managing patients with food allergies remain limited. We have conducted a systematic review of literature published within the last 5 years on the diagnosis and management of food a...

Food allergy is defined as an abnormal immunological reaction to food proteins, which causes an adverse clinical reaction. Today 4–6% of children and 1–3% of adults are affected with food allergy in Europe (Mills et al., 2007), while in the USA 6– 8% of children and 4% of adults are affected (Gupta et al., 2008). The incidence of food allergy has been increasing over the years, and to date, no ...

Introduction Food avoidance is still considered the gold-standard treatment for food allergy (FA). However, recently it has been consolidating the theory that, where possible, the food intake might facilitate the induction of desensitization and tolerance, resulting more effective and safer -if we consider the possibility of accidental ingestionthan a strict avoidance diet [1]. Furthermore, spe...

Over the past decades, major allergens of the most important allergenic foods have been identified, isolated, cloned and expressed as recombinant molecules. This development has sparked off a revolution in allergology towards molecular approaches for diagnosis and therapy. The roles of individual molecules in clinical phenotypes are being elucidated rapidly. One of the first clear examples that...

BACKGROUND The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. METHODS We will undertake a systematic review, which will involve searching internationa...

Background Oral immunotherapy is an emerging therapy currently under investigation for the treatment of food allergy [1]. Underlying mechanisms are thought to involve a switch in the food specific T cell response from Th2 to either Th1, Tr1 and/or Treg. It is unknown whether this change in response results from re-education of existing pathological food-specific T cells or from their replacemen...

The principle of cancer immunotherapy includes various methods of manipulations to influence immune responses against tumors in both humans and animals. This advanced technology of hybridoma production provided the necessary skills to efficiently produce highly specific monoclonal antibodies (mAb). Radioactively-tagged antibodies which are applied in radioimmunotherapy (RIT), can target adjacen...