Thyroid is a H-shaped gland localised in front of trachea at the base of the neck, whose main functions are the synthesis, the storage and the secretion of thyroid hormones under the control of the hypothalamic–pituitary axis. Thyroid is comprised of spherical follicles filled with colloid that are lined by cuboidal/flat epithelial cells denoted follicular cells (or thyrocytes). The other hormo...

Thyroid carcinoma with distant metastases at initial presentation, is uncommon. Skull metastases occur very rarely, with a reported incidence of 2.5-5.8%. Here we report two cases of follicular thyroid cancer with skull involvement, and describe the diagnostic and therapeutic approach to metastatic thyroid cancer. We present the cases of a 70-year-old female and a 74-year-old female who present...

The development of molecular biomarkers (BMs) of follicular thyroid carcinoma is aimed at advancing diagnosis of follicular neoplasm, as histological examination of those tumors does not lend itself to definitive diagnosis of carcinoma. We assessed the relative levels of expression of 6 genes: CCND2, PCSK2, PLAB, RAP2A, TSHR, and IGF-1R in archived thyroid tissue. The quantitative real-time PCR...

Note Papillary Thyroid Carcinomas (PTCs) derives from the thyroid follicular cells, as the other type of welldifferentiated thyroid carcinomas, the follicular ones; however these differentiated thyroid cancers are regarded as different entities: The follicular carcinoma, solitary and encapsulated, is associated with endemic goiter, a diet with low iodine intake and metastatizes almost exclusive...

The differential diagnosis of a follicular lesion/neoplasm in thyroid FNA specimens includes hyperplastic/adenomatoid nodule, follicular adenoma and carcinoma, and follicular variant of papillary thyroid carcinoma. In our laboratory we separate follicular lesions of thyroid into hyperplastic/adenomatoid nodule (HN), follicular neoplasm (FON) and follicular derived neoplasm with focal nuclear fe...

Background: Fine needle aspiration (FNA) has led to a decrease in unnecessary surgeries for thyroid nodules. This study was designed to compare diagnostic value of FNA and frozen section methods in the follicular lesions. Methods: This is a cross-sectional study based on the medical records of 42 patients who were referred to surgery clinic of Rasool-e-Akram hospital in Tehran with complain...

Background: Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5–8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid Received: April 22, 2014 Accepted after rev...

Mixed medullary-follicular carcinoma is an uncommon tumor of the thyroid. It is characterized by histological and immunohistochemical features of both follicular and parafollicular C cells. We report two female patients, aged 26 and 78 years, with mixed medullary-follicular carcinoma. Histologically, the tumors are composed of follicular carcinoma areas and solid nests of polygonal cells consis...

background: fine needle aspiration (fna) has led to a decrease in unnecessary surgeries for thyroid nodules. this study was designed to compare diagnostic value of fna and frozen section methods in the follicular lesions. methods: this is a cross-sectional study based on the medical records of 42 patients who were referred to surgery clinic of rasool-e-akram hospital in tehran with complaint of...