Recent studies in protein folding suggest that native state topology plays a dominant role in determining the folding mechanism, yet an analogous statement has not been made for RNA, most likely due to the strong coupling between the ionic environment and conformational energetics that make RNA folding more complex than protein folding. Applying a distributed computing architecture to sample ne...

We investigated the impact of hydrodynamic interactions (HI) on protein folding using a coarse-grained model. The extent of the impact of hydrodynamic interactions, whether it accelerates, retards, or has no effect on protein folding, has been controversial. Together with a theoretical framework of the energy landscape theory (ELT) for protein folding that describes the dynamics of the collecti...

The effects of sodium n-dodecyl sulphate (SDS) on the structure of histone HI has been studied by a combination of e:quilibrium dialysis, U.V. spectroscopy ; polyacrylamide gel electrophoresis, protein titration and viscometery techniques using, 2.5 mM phosphate buffer, pH 6.4. The interaction of H, and SDS in contrast tomanyothel-protein-SDS interactions is organized between V 40 to 70. A...

Protein folding conformations take the form of networks, sets of conformations (vertices) joined together in pairs by links or edges. Protein folding conformation network is a complex network, and has scale-free property that many networks have in common. Understanding the scale-free property in the network of protein folding conformation, one can find the better conformation of protein folding...

endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway.  unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...

Following the outbreak of COVID–19 pandemic, ATLAS experiment considered how it could most efficiently contribute using its distributed computing resources. After considering many suggestions, examining several potential projects and following advice CERN COVID Task Force, was decided to engage in Folding@Home initiative, which provides payloads that perform protein folding simulations. This pa...