نتایج جستجو برای: folate targeting
تعداد نتایج: 159458 فیلتر نتایج به سال:
Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer development have reignited interest in the tumor-associated antigen Folate Receptor alpha (FRα). FRα is a glycosylphosphatidylinositol (GPI)-anchored membrane protein. Its overexpression in tumors such as ovarian, breast and lung cancers, low an...
" …carefully designed screening strategies of recombinant antibody libraries have the potential to lead to the identification of ideal targeting reagents for both in vitro and in vivo uses. " Novel targeting strategies using recombinant antibodies for early diagnosis and therapy of ovarian cancer lipid-based or paramagnetic nanoparticles to highly versatile polymers and viral capsids, can be us...
Since recombinant viral vectors have been associated with serious side effects, such as immunogenicity and oncogenicity, synthetic delivery systems represent a realistic alternative for achieving efficacy in gene therapy. A major challenge for non-viral nanocarriers is the optimization of transgene expression in the targeted cells. This goal can be achieved by fine-tuning the chemical carriers ...
Prior studies suggested that nanoparticle drug delivery might improve the therapeutic response to anticancer drugs and allow the simultaneous monitoring of drug uptake by tumors. We employed modified PAMAM dendritic polymers <5 nm in diameter as carriers. Acetylated dendrimers were conjugated to folic acid as a targeting agent and then coupled to either methotrexate or tritium and either fluore...
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